Neuroprotection induced by protease-activated receptor 2 activation is independent of Gq signalling

• Published in: Brain and neuroscience advances Vol. 9; p. 23982128251345673
• Main Authors: Moudio, Serge, Nuthall, Hugh N., Bushell, Trevor J.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2025
• Subjects: receptor internalisation; G-protein coupled receptor; calcium signalling; neuroprotection; Protease-activated receptor 2

Protease-activated receptor 2 is proposed to be a novel target for several inflammation-related diseases but its role in the central nervous system remains unclear. Protease-activated receptor 2 activation is protective in cell death and excitotoxicity assays whereas examination into the role of pro...