Prostaglandin E 2 -Induced Immune Suppression via Cytotoxic T-Lymphocyte Antigen 4 in Paratuberculosis

• Published in: Infection and immunity Vol. 90; no. 10; p. e0021022
• Main Authors: Sajiki, Yamato, Konnai, Satoru, Watari, Kei, Okagawa, Tomohiro, Tanaka, Akina, Kawaji, Satoko, Nagata, Reiko, Maekawa, Naoya, Suzuki, Yasuhiko, Kato, Yukinari, Murata, Shiro, Mori, Yasuyuki, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: United States 20.10.2022
• Subjects: Abatacept - metabolism; Animals; Antibodies, Monoclonal - metabolism; Cattle; Cattle Diseases; CTLA-4 Antigen - metabolism; Immunosuppression Therapy; Interferon-gamma; Leukocytes, Mononuclear; Mycobacterium avium subsp. paratuberculosis; Paratuberculosis; Prostaglandins - metabolism; Prostaglandins E - metabolism; Tumor Necrosis Factor-alpha - metabolism; EP4; PGE2; CTLA-4; cattle; Johne’s disease

Paratuberculosis is a chronic enteritis of ruminants caused by the facultative intracellular pathogen Mycobacterium avium subsp. paratuberculosis . The Th1 response inhibits the proliferation of M. avium subsp. paratuberculosis during the early subclinical stage. Paratuberculosis is a chronic enteri...