Aliphatic 18 F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates

• Published in: ChemMedChem Vol. 16; no. 17; pp. 2612 - 2622
• Main Authors: Bratteby, Klas, Shalgunov, Vladimir, Herth, Matthias Manfred
• Format: Journal Article
• Language: English
• Published: Germany 06.09.2021
• Subjects: Fluorine Radioisotopes; Halogenation; Humans; Molecular Conformation; Positron-Emission Tomography; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; aliphatic; fluorine-18; SN2; base sensitivity; radiochemistry

Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable F...