Aliphatic 18 F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates
Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable F...
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| Published in | ChemMedChem Vol. 16; no. 17; pp. 2612 - 2622 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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06.09.2021
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| Abstract | Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for
F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable
F-labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic
F-fluorination of base-sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods. |
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| AbstractList | Aliphatic fluorine‐18 radiolabeling is the most commonly used method to synthesize tracers for PET‐imaging. With an increasing demand for
18
F‐radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable
18
F‐labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic
18
F‐fluorination of base‐sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods. Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for F-radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable F-labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic F-fluorination of base-sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods. |
| Author | Bratteby, Klas Shalgunov, Vladimir Herth, Matthias Manfred |
| Author_xml | – sequence: 1 givenname: Klas surname: Bratteby fullname: Bratteby, Klas organization: Department of Clinical Physiology, Nuclear Medicine & PET Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark – sequence: 2 givenname: Vladimir surname: Shalgunov fullname: Shalgunov, Vladimir organization: Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 2100, Copenhagen, Denmark – sequence: 3 givenname: Matthias Manfred orcidid: 0000-0002-7788-513X surname: Herth fullname: Herth, Matthias Manfred organization: Department of Clinical Physiology, Nuclear Medicine & PET Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34169672$$D View this record in MEDLINE/PubMed |
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| Keywords | aliphatic fluorine-18 SN2 base sensitivity radiochemistry |
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| Snippet | Aliphatic fluorine-18 radiolabeling is the most commonly used method to synthesize tracers for PET-imaging. With an increasing demand for
F-radiotracers for... Aliphatic fluorine‐18 radiolabeling is the most commonly used method to synthesize tracers for PET‐imaging. With an increasing demand for 18 F‐radiotracers for... |
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| SubjectTerms | Fluorine Radioisotopes Halogenation Humans Molecular Conformation Positron-Emission Tomography Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry |
| Title | Aliphatic 18 F-Radiofluorination: Recent Advances in the Labeling of Base-Sensitive Substrates |
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