Anticipating emerging biotechnology threats
This article discusses the contingencies and complexities of CRISPR. It outlines key problems regarding off-target effects and replication of experimental work that are important to consider in light of CRISPR’s touted ease of use and diffusion. In light of literature on the sociotechnical dimension...
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| Published in | Politics and the life sciences Vol. 37; no. 2; pp. 203 - 219 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New York, USA
Cambridge University Press
23.10.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This article discusses the contingencies and complexities of CRISPR. It outlines key problems regarding off-target effects and replication of experimental work that are important to consider in light of CRISPR’s touted ease of use and diffusion. In light of literature on the sociotechnical dimensions of the life sciences and biotechnology and literature on former bioweapons programs, this article argues that we need more detailed empirical case studies of the social and technical factors shaping CRISPR and related gene-editing techniques in order to better understand how they may be different from other advances in biotechnology — or whether similar features remain. This information will be critical to better inform intelligence practitioners and policymakers about the security implications of new gene-editing techniques. |
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| AbstractList | This article discusses the contingencies and complexities of CRISPR. It outlines key problems regarding off-target effects and replication of experimental work that are important to consider in light of CRISPR's touted ease of use and diffusion. In light of literature on the sociotechnical dimensions of the life sciences and biotechnology and literature on former bioweapons programs, this article argues that we need more detailed empirical case studies of the social and technical factors shaping CRISPR and related gene-editing techniques in order to better understand how they may be different from other advances in biotechnology - or whether similar features remain. This information will be critical to better inform intelligence practitioners and policymakers about the security implications of new gene-editing techniques. |
| Author | Ouagrham-Gormley, Sonia Ben Vogel, Kathleen M. |
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| Keywords | replication CRISPR biosecurity diffusion off-target effects gene editing technical challenges biological weapons intelligence |
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