Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity

• Published in: Molecular pharmacology Vol. 77; no. 3; pp. 327 - 338
• Main Authors: Strachan, Ryan T, Sciaky, Noah, Cronan, Mark R, Kroeze, Wesley K, Roth, Bryan L
• Format: Journal Article
• Language: English
• Published: United States 01.03.2010
• Subjects: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Gene Deletion; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - physiology; Mice; Mice, Knockout; Receptor, Serotonin, 5-HT2A - physiology; Ribosomal Protein S6 Kinases, 90-kDa - deficiency; Ribosomal Protein S6 Kinases, 90-kDa - genetics; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists - pharmacology

The concept of functional selectivity has now thoroughly supplanted the previously entrenched notion of intrinsic efficacy by explaining how agonists and antagonists exhibit a range of efficacies for distinct receptor-mediated responses. It is noteworthy that functional selectivity accommodates sign...