A Novel Allogeneic Cell Therapy That Targets Pathogenic Autoantibodies for the Treatment of Immune Thrombocytopenia

• Published in: Blood Vol. 138; no. Supplement 1; p. 1001
• Main Authors: Patel-Hett, Sunita, Giannini, Silvia, Peters, Christian, Dykstra, Brad, Lehmann, Marcus, Russo, Ashley J, Kohnke, Dora E, Carpenter, Ryan, Tomczak, Lindsay, Lazarus, Douglas, Masuko, Sayaka, Leung, Amanda, Meredith, Angelique, Pete, Sophia, Lee, Po-Shun, Falb, Dean
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 23.11.2021

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts (<100x10 9/L) and increased risk of bleeding. ITP is predominantly driven by immunoglobulin G (IgG)-autoantibodies directed against platelet surface antigens resulting in platelet destruction by the splee...