Uncovering novel pathogenic variants and pathway mutations in triple-negative breast cancer among the endogamous mizo tribe

• Published in: Breast cancer research and treatment
• Main Authors: Pachuau, Lalawmpuii, Lalremmawia, H, Ralte, Lalengkimi, Vanlalpeka, Johan, Pautu, Jeremy Lalrinsanga, Chenkual, Saia, Zomuana, Thomas, Lalruatfela, Sailo Tlau, Zohmingthanga, John, Chhakchhuak, Lalchhandama, Varma, Ashok K, Kumar, Nachimuthu Senthil
• Format: Journal Article
• Language: English
• Published: Netherlands 09.10.2024
• Subjects: Pathogenic variant; Mutational signature; Whole-exome sequencing; Somatic and germline variants; Triple-negative breast cancer

The incidence of triple-negative breast cancer (TNBC) in India is higher compared to Western populations. The objective of this study is to identify novel and less reported variants in TNBC in Mizoram, a state with a high cancer incidence in India. We analysed whole exome sequencing data from triple...