Clinical Study of Platelet Aggregation in Patients with Vertigo and Dizziness

• Published in: Equilibrium Research Vol. 56; no. 3; pp. 284 - 295
• Main Author: Kashiwagi, Noriko
• Format: Journal Article
• Language: English
• Published: Japan Society for Equilibrium Research 1997
• Subjects: hyperlipidemia; platelet aggregability; stress; vascular occlusive disease
• DOI: 10.3757/jser.56.284
• ISSN: 0385-5716

Platelet aggregation in 185 patients with vertigo and dizziness (174 mild and 11 serious cases) were studied between November 1989 and April 1996, also 63 healthy subjects and 20 cases of vascular occlusive diseases in the post-acute phase (12 patients with ischemic heart disease and 8 with cerebral infarction) were studied as control groups. This study evaluated the maximum aggregability (aggregability) induced by 2 μg/ml COLLAGEN and 2 μM ADP. The results are as follows. 1. Aggregability of patient sera was significantly higher than that of healthy subjects. However, there was no significant difference between groups with peripheral, central and other disorders. 2. Factors affecting aggregability were stress in patients with peripheral disorders and cholesterol in those of central disorders. 3. The mean value of aggregability of 185 patients was between the value in healthy subjects and that in patients with vascular disorders. 4. Aggregability at a high level persisted for a long period even when the patient became asymptomatic. And during the recovery, when stress or hyperlipidemia was persistent, aggregability could increase. Therefore, even after symptoms disappear, risk factors such as stress or hyperlipidemia should be avoided.