S939 Correlation of Ustekinumab Trough Levels With Outcomes in Inflammatory Bowel Disease
The primary outcomes were the correlation of UST level with clinical remission (per physician global assessment), endoscopic healing (absence of ulcers/erosions in Crohn’s disease (CD) and Mayo endoscopic score ≤ 1 for ulcerative colitis (UC)), and normal serum C-reactive protein (CRP) (≤ 5 mg/L). A...
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Published in | The American journal of gastroenterology Vol. 118; no. 10S; pp. S703 - S704 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
01.10.2023
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Subjects | |
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Abstract | The primary outcomes were the correlation of UST level with clinical remission (per physician global assessment), endoscopic healing (absence of ulcers/erosions in Crohn’s disease (CD) and Mayo endoscopic score ≤ 1 for ulcerative colitis (UC)), and normal serum C-reactive protein (CRP) (≤ 5 mg/L). A cutoff UST level of 4.8 µg/ml yielded the highest area under the curve (AUC) of 0.73 (95% CI: 0.61-0.80) to predict a normal CRP followed by a level cutoff of 3.5 µg/ml which yielded an AUC of 0.66 (95% CI: 0.52- 0.81) to predict endoscopic healing (Table 1). C-reactive protein; AUC: area under the curve; CI: confidence interval Outcomes Cut-Off UST levels (μg/ml) Sensitivity (%) Specificity (%) AUC 95% CI Clinical remission 4.4 52 62 0.62 [0.49-0.75] Endoscopic healing 3.5 76 48 0.66 [0.52-0.81] Normal CRP 4.8 56 87 0.73 [0.61-0.86] Author Notes *Presenter |
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AbstractList | The primary outcomes were the correlation of UST level with clinical remission (per physician global assessment), endoscopic healing (absence of ulcers/erosions in Crohn’s disease (CD) and Mayo endoscopic score ≤ 1 for ulcerative colitis (UC)), and normal serum C-reactive protein (CRP) (≤ 5 mg/L). A cutoff UST level of 4.8 µg/ml yielded the highest area under the curve (AUC) of 0.73 (95% CI: 0.61-0.80) to predict a normal CRP followed by a level cutoff of 3.5 µg/ml which yielded an AUC of 0.66 (95% CI: 0.52- 0.81) to predict endoscopic healing (Table 1). C-reactive protein; AUC: area under the curve; CI: confidence interval Outcomes Cut-Off UST levels (μg/ml) Sensitivity (%) Specificity (%) AUC 95% CI Clinical remission 4.4 52 62 0.62 [0.49-0.75] Endoscopic healing 3.5 76 48 0.66 [0.52-0.81] Normal CRP 4.8 56 87 0.73 [0.61-0.86] Author Notes *Presenter |
Author | Fine, Sean Alzahrani, Raneem Al-Bawardy, Badr Petrov, Jessica C. Mohamed, Gamal |
Author_xml | – sequence: 1 givenname: Jessica C. surname: Petrov fullname: Petrov, Jessica C. organization: Yale School of Medicine, New Haven, CT – sequence: 2 givenname: Sean surname: Fine fullname: Fine, Sean organization: Warren Alpert Medical School of Brown University, Providence, RI – sequence: 3 givenname: Raneem surname: Alzahrani fullname: Alzahrani, Raneem organization: King Faisal Specialist Hospital, Riyadh, Ar Riyad, Saudi Arabia – sequence: 4 givenname: Gamal surname: Mohamed fullname: Mohamed, Gamal organization: King Faisal Specialist Hospital, Riyadh, Ar Riyad, Saudi Arabia – sequence: 5 givenname: Badr surname: Al-Bawardy fullname: Al-Bawardy, Badr organization: King Faisal Specialist Hospital, Riyadh, Ar Riyad, Saudi Arabia |
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Title | S939 Correlation of Ustekinumab Trough Levels With Outcomes in Inflammatory Bowel Disease |
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