Chromatin structure can introduce systematic biases in genome-wide analyses of Plasmodium falciparum

• Published in: Open research Europe Vol. 2; p. 75
• Main Authors: Baumgarten, Sebastian, Bryant, Jessica
• Format: Journal Article
• Language: English
• Published: F1000 Research Limited on behalf of the European Commission 2022
• Subjects: Biochemistry, Molecular Biology; Life Sciences; Microbiology and Parasitology; Molecular biology; Parasitology; ChIP-seq; Plasmodium falciparum; read alignment; Chromatin structure

Background: The maintenance, regulation, and dynamics of heterochromatin in the human malaria parasite, Plasmodium falciparum, has drawn increasing attention due to its regulatory role in mutually exclusive virulence gene expression and the silencing of key developmental regulators. The advent of ge...