Marrow Fat Content and Composition in β‐Thalassemia: A Study using 1 H‐MRS

• Published in: Journal of magnetic resonance imaging Vol. 53; no. 1; pp. 190 - 198
• Main Authors: Ismail, Umi Nabilah, Azlan, Che Ahmad, Khairullah, Shasha, Azman, Raja Rizal, Omar, Nur Farhayu, Md Shah, Mohammad Nazri, Yeong, Chai Hong, Jackson, Nicholas, Ng, Kwan Hoong
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Adipose Tissue - diagnostic imaging; beta-Thalassemia - diagnostic imaging; Bone Marrow - diagnostic imaging; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Prospective Studies; bone marrow fat; ineffective erythropoiesis; hematopoiesis; β-thalassemia; MRS; marrow adipose tissue (MAT)

β-thalassemia is a genetic disease that causes abnormal production of red blood cells (ineffective erythropoiesis, IE). IE is a condition known to change bone marrow composition. To evaluate the effect of IE on the marrow fat content and fat unsaturation levels in the proximal femur using H-MRS. Pro...