Analysis of Ca 2 + mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

• Published in: Cellular microbiology Vol. 19; no. 4
• Main Authors: Stewart, Rebecca J, Whitehead, Lachlan, Nijagal, Brunda, Sleebs, Brad E, Lessene, Guillaume, McConville, Malcolm J, Rogers, Kelly L, Tonkin, Christopher J
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Calcium Signaling; Cells, Cultured; Cyclic GMP - metabolism; Cyclic GMP-Dependent Protein Kinases - metabolism; Host-Parasite Interactions; Humans; Toxoplasma - pathogenicity; Toxoplasma - physiology; Toxoplasmosis - parasitology

Host cell invasion, exit and parasite dissemination is critical to the pathogenesis of apicomplexan parasites such as Toxoplasma gondii and Plasmodium spp. These processes are regulated by intracellular Ca signaling although the temporal dynamics of Ca fluxes and down-stream second messenger pathway...