Abstract 3005: The impact of mitochondrially targeted oncology agents on mitochondrial DNA (mtDNA) integrity

Abstract Reactive oxygen species (ROS) are natural byproducts of mitochondrial oxidative phosphorylation. Dysfunction in electron shuttling leads to enhanced ROS production that is notorious for inflicting damage to macromolecules. Mitochondrial DNA (mtDNA) is particularly sensitive to ROS as it is...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 3005
Main Authors Pokrzywinski, Kaytee L., Biel, Thomas G., Kryndushkin, Dmitry, Rao, V. Ashutosh
Format Journal Article
LanguageEnglish
Published 15.07.2016
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