A case of large central mucoepidermoid carcinoma in the mandible considered to induce attack of syncope
Central mucoepidermoid carcinoma is an uncommon tumor, accounting for 2% to 3% of all mucoepidermoid carcinomas. Meanwhile, a head and neck tumor rarely causes an attack of syncope. We describe a case of syncope considered to be caused by a large central mucoepidermoid carcinoma in the mandible. A 6...
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Published in | Japanese Journal of Oral and Maxillofacial Surgery Vol. 64; no. 9; pp. 545 - 549 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English Japanese |
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Japanese Society of Oral and Maxillofacial Surgeons
20.09.2018
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Abstract | Central mucoepidermoid carcinoma is an uncommon tumor, accounting for 2% to 3% of all mucoepidermoid carcinomas. Meanwhile, a head and neck tumor rarely causes an attack of syncope. We describe a case of syncope considered to be caused by a large central mucoepidermoid carcinoma in the mandible. A 66-year-old man was referred to our clinic to receive treatment for a right mandibular lesion and to determine the cause of repeated attacks of syncope. Computed tomography showed that the right side of the mandible was remarkably expanded, and the parapharyngeal space was compressed by an expanded right mandibular tumor. Tumor biopsy was performed, and a mucoepidermoid carcinoma of the mandible was definitively diagnosed. No evidence of metastasis was evident on positron emission tomography. With the patient under general anesthesia, we performed a right hemimandibulectomy, right neck dissection, and immediate reconstruction using a pectoralis major myocutaneous flap and a reconstruction plate with condyle. We found no evidence of local recurrence or regional and distant metastasis at the 4-year postoperative follow-up. In addition, no attack of syncope occurred after the operation. |
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AbstractList | Central mucoepidermoid carcinoma is an uncommon tumor, accounting for 2% to 3% of all mucoepidermoid carcinomas. Meanwhile, a head and neck tumor rarely causes an attack of syncope. We describe a case of syncope considered to be caused by a large central mucoepidermoid carcinoma in the mandible. A 66-year-old man was referred to our clinic to receive treatment for a right mandibular lesion and to determine the cause of repeated attacks of syncope. Computed tomography showed that the right side of the mandible was remarkably expanded, and the parapharyngeal space was compressed by an expanded right mandibular tumor. Tumor biopsy was performed, and a mucoepidermoid carcinoma of the mandible was definitively diagnosed. No evidence of metastasis was evident on positron emission tomography. With the patient under general anesthesia, we performed a right hemimandibulectomy, right neck dissection, and immediate reconstruction using a pectoralis major myocutaneous flap and a reconstruction plate with condyle. We found no evidence of local recurrence or regional and distant metastasis at the 4-year postoperative follow-up. In addition, no attack of syncope occurred after the operation. |
Author | MIYATA, Yukinaga BASUGI, Akihiko KANAI, Ikuyo EGUCHI, Takanori HASEBE, Mitsuhiko HAMADA, Yoshiki |
Author_xml | – sequence: 1 fullname: EGUCHI, Takanori organization: Department of Oral and Maxillofacial Surgery, Toshibarinkan Hospital – sequence: 2 fullname: BASUGI, Akihiko organization: Department of Oral and Maxillofacial Surgery, Toshibarinkan Hospital – sequence: 3 fullname: KANAI, Ikuyo organization: Department of Oral and Maxillofacial Surgery, Toshibarinkan Hospital – sequence: 4 fullname: MIYATA, Yukinaga organization: Department of Oral and Maxillofacial Surgery, Toshibarinkan Hospital – sequence: 5 fullname: HASEBE, Mitsuhiko organization: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University – sequence: 6 fullname: HAMADA, Yoshiki organization: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University |
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References | 5) Inagaki M, Yuasa K, et al : Mucoepidermoid carcinoma in the mandible: findings of panoramic radiography and computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85: 613-618, 1998. 2) El-Naggar AK, Chan JKC, et al : WHO Classification of Head and Neck Tumours. 4th Edition, IARC, Lyon 2017, 163-164. 17) Noroozi N, Ali M, et al : Carotid sinus syndrome as the presenting symptom of cystadenolymphoma. Head Face Med 8: 31, 2012. 8) 五藤晃義, 山口万枝, 他:囊胞様骨透過像を呈し8年の病悩期間後に確定診断され骨中心性と考えられた粘表皮癌の1例.日口診誌 12: 539-542, 1999. 12) Eversole LR, Sabes WR, et al : Aggressive growth and neoplastic potential of odontogenic cysts: with special reference to central epidermoid and mucoepidermoid carcinomas. Cancer 35: 270-282, 1975. 9) Roh JL, Ryu CH, et al : Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med 48: 240-246, 2007. 11) Browand BC and Waldron CA : Central mucoepidermoid tumors of the jaws. Report of nine cases and review of the literature. Oral Surg Oral Med Oral Pathol 40: 631-643, 1975. 3) Macdonald DR, Strong E, et al : Syncope from head and neck cancer. J Neurooncol 1: 257-267, 1983. 6) Simon D, Somanathan T, et al : Central Mucoepidermoid carcinoma of mandible - A case report and review of the literature. World J Surg Oncol 1: 1, 2003. 4) 間多祐輔, 越塚慶一, 他:反復する失神発作をきたした頭頸部悪性腫瘍症例の臨床的検討.頭頸部外 25: 429-435, 2016. 13) Brookstone MS and Huvos AG : Central salivary gland tumors of the maxilla and mandible: a clinicopathologic study of 11 cases with an analysis of the literature. J Oral Maxillofac Surg 50: 229-236, 1992. 16) Nakahira M, Nakatani H, et al : Syncope as a sign of occult malignant recurrence in the retropharyngeal and parapharyngeal space: CT and MR imaging findings in four cases. AJNR Am J Neuroradiol 23: 1257-1260, 2002. 15) 木村幸紀, 花澤智美, 他:骨新生像を伴った下顎骨中心性粘表皮癌の1例.口科誌 58: 27-33, 2009. 1) Kochaji N, Goossens A, et al : Central mucoepidermoid carcinoma: case report, literature review for missing and available information and guideline proposal for coming case reports. Oral Oncol (EXTRA) 40: 95-105, 2004. 10) Bouquot JE, Gnepp DR, et al : Intraosseous salivary tissue: jawbone examples of choristomas, hamartomas, embryonic rests, and inflammatory entrapment: another histogenetic source for intraosseous adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90: 205-217, 2000. 14) Li Y, Li LJ, et al : Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases. J Oral Maxillofac Surg 66: 2247-2253, 2008. 7) Tucci R, Matizonkas-Antonio LF, et al : Central mucoepidermoid carcinoma: report of a case with 11 years’ evolution and peculiar macroscopical and clinical characteristics. Med Oral Patol Oral Cir Bucal 14: E283-286, 2009. 11 12 13 14 1 2 3 4 5 6 7 8 9 10 |
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Title | A case of large central mucoepidermoid carcinoma in the mandible considered to induce attack of syncope |
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