m6A-mediated gluconeogenic enzyme PCK1 upregulation protects against hepatic ischemia-reperfusion injury
Background and Aims: Ischemia-reperfusion (I/R) injury frequently occurs during liver surgery, representing a major reason for liver failure and graft dysfunction after operation. The metabolic shift from oxidative phosphorylation to glycolysis during ischemia increased glucose consumption and accel...
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Published in | Hepatology (Baltimore, Md.) |
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12.12.2023
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Abstract | Background and Aims: Ischemia-reperfusion (I/R) injury frequently occurs during liver surgery, representing a major reason for liver failure and graft dysfunction after operation. The metabolic shift from oxidative phosphorylation to glycolysis during ischemia increased glucose consumption and accelerated lactate production. We speculate that donor livers will initiate gluconeogenesis, the reverse process of glycolysis in theory, to convert noncarbohydrate carbon substrates (including lactate) to glucose to reduce the loss of hepatocellular energy and foster glycogen storage for use in the early postoperative period, thus improving post-transplant graft function. Approach and Results: By analyzing human liver specimens before and after hepatic I/R injury, we found that the rate-limiting enzyme of gluconeogenesis, PCK1, was significantly induced during liver I/R injury. Mouse models with liver I/R operation and hepatocytes treated with hypoxia/reoxygenation confirmed upregulation of PCK1 during I/R stimulation. Notably, high PCK1 level in human post-I/R liver specimens was closely correlated with better outcomes of liver transplantation. However, blocking gluconeogenesis with PCK1 inhibitor aggravated hepatic I/R injury by decreasing glucose level and deepening lactate accumulation, while overexpressing PCK1 did the opposite. Further mechanistic study showed that methyltransferase 3-mediated RNA N6-methyladinosine modification contributes to PCK1 upregulation during hepatic I/R injury, and hepatic-specific knockout of methyltransferase 3 deteriorates liver I/R injury through reducing the N6-methyladinosine deposition on PCK1 transcript and decreasing PCK1 mRNA export and expression level. Conclusions: Our study found that activation of the methyltransferase 3/N6-methyladinosine-PCK1-gluconeogenesis axis is required to protect against hepatic I/R injury, providing potential intervention approaches for alleviating hepatic I/R injury during liver surgery. |
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AbstractList | Background and Aims: Ischemia-reperfusion (I/R) injury frequently occurs during liver surgery, representing a major reason for liver failure and graft dysfunction after operation. The metabolic shift from oxidative phosphorylation to glycolysis during ischemia increased glucose consumption and accelerated lactate production. We speculate that donor livers will initiate gluconeogenesis, the reverse process of glycolysis in theory, to convert noncarbohydrate carbon substrates (including lactate) to glucose to reduce the loss of hepatocellular energy and foster glycogen storage for use in the early postoperative period, thus improving post-transplant graft function. Approach and Results: By analyzing human liver specimens before and after hepatic I/R injury, we found that the rate-limiting enzyme of gluconeogenesis, PCK1, was significantly induced during liver I/R injury. Mouse models with liver I/R operation and hepatocytes treated with hypoxia/reoxygenation confirmed upregulation of PCK1 during I/R stimulation. Notably, high PCK1 level in human post-I/R liver specimens was closely correlated with better outcomes of liver transplantation. However, blocking gluconeogenesis with PCK1 inhibitor aggravated hepatic I/R injury by decreasing glucose level and deepening lactate accumulation, while overexpressing PCK1 did the opposite. Further mechanistic study showed that methyltransferase 3-mediated RNA N6-methyladinosine modification contributes to PCK1 upregulation during hepatic I/R injury, and hepatic-specific knockout of methyltransferase 3 deteriorates liver I/R injury through reducing the N6-methyladinosine deposition on PCK1 transcript and decreasing PCK1 mRNA export and expression level. Conclusions: Our study found that activation of the methyltransferase 3/N6-methyladinosine-PCK1-gluconeogenesis axis is required to protect against hepatic I/R injury, providing potential intervention approaches for alleviating hepatic I/R injury during liver surgery. |
Author | Zhang, Qi Chu, Jiajie Zhang, Yiwang Zhou, Zhuowei Pan, Lijie Tu, Silin Huang, Yiju Liu, Xiao Sun, Yuetong Xu, Yan Tu, Dan Zhang, Yihan Chen, Wenjie Liang, Xiaoqi Chen, Huaxin Dong, Shuai Yu, Shanshan Ge, Mian Li, Yanli Liu, Chang |
Author_xml | – sequence: 1 givenname: Shanshan orcidid: 0000-0003-4055-9071 surname: Yu fullname: Yu, Shanshan organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 2 givenname: Xiao surname: Liu fullname: Liu, Xiao organization: Department of Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 3 givenname: Yan orcidid: 0000-0001-5653-291X surname: Xu fullname: Xu, Yan organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 4 givenname: Lijie surname: Pan fullname: Pan, Lijie organization: Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 5 givenname: Yihan surname: Zhang fullname: Zhang, Yihan organization: Department of Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 6 givenname: Yanli surname: Li fullname: Li, Yanli organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 7 givenname: Shuai surname: Dong fullname: Dong, Shuai organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 8 givenname: Dan surname: Tu fullname: Tu, Dan organization: Department of Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 9 givenname: Yuetong surname: Sun fullname: Sun, Yuetong organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 10 givenname: Yiwang surname: Zhang fullname: Zhang, Yiwang organization: Department of Pathology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 11 givenname: Zhuowei surname: Zhou fullname: Zhou, Zhuowei organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 12 givenname: Xiaoqi surname: Liang fullname: Liang, Xiaoqi organization: Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 13 givenname: Yiju surname: Huang fullname: Huang, Yiju organization: Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 14 givenname: Jiajie surname: Chu fullname: Chu, Jiajie organization: Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 15 givenname: Silin surname: Tu fullname: Tu, Silin organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 16 givenname: Chang surname: Liu fullname: Liu, Chang organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 17 givenname: Huaxin surname: Chen fullname: Chen, Huaxin organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 18 givenname: Wenjie surname: Chen fullname: Chen, Wenjie organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 19 givenname: Mian orcidid: 0000-0002-5197-3940 surname: Ge fullname: Ge, Mian organization: Department of Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China – sequence: 20 givenname: Qi orcidid: 0000-0001-9916-8919 surname: Zhang fullname: Zhang, Qi organization: Biotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Cell-gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China |
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Cites_doi | 10.1053/j.gastro.2020.11.013 10.3109/08860229209047656 10.1038/s41467-022-32169-4 10.1007/s12035-020-02251-3 10.1093/nar/gks932 10.1161/01.RES.55.6.816 10.1113/jphysiol.2009.183996 10.1002/lt.20911 10.15252/embj.2020105977 10.1007/BF02618288 10.1038/s42255-020-0238-1 10.1002/hep.32133 10.1172/JCI161713 10.1097/00000658-199209000-00003 10.1042/bj1380387 10.1101/pdb.prot087163 10.1016/j.gendis.2022.02.010 10.1097/00007890-198912000-00002 10.1016/j.trecan.2018.11.003 10.1016/j.cmet.2018.03.008 10.1097/00007890-199106000-00007 10.1007/s00423-020-01965-1 10.1038/s41575-021-00549-8 10.1146/annurev-nutr-080508-141134 10.1016/j.febslet.2005.03.097 10.1016/j.molcel.2022.05.029 10.1038/cr.2017.100 10.3390/cells11020291 10.1002/hep.510290407 10.1038/s41392-021-00699-w 10.1161/01.RES.37.6.742 10.1039/D2NP00086E 10.1038/nmeth.3317 10.1038/nrgastro.2012.225 10.1038/nprot.2012.148 10.1038/s41576-020-00295-8 10.1016/0011-2240(91)90027-L 10.1016/j.jhep.2020.04.009 10.1016/j.transproceed.2016.08.013 10.1097/00007890-199603270-00004 10.1016/j.molmet.2021.101257 10.1210/jc.2018-00619 10.1016/j.jhep.2017.11.022 10.1097/00007890-199210000-00043 10.1016/0016-5085(94)90819-2 10.1093/nar/gkw104 10.1093/bioinformatics/btt171 |
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References | Caraceni (R4-20240827) 1999; 29 Zhang (R28-20240827) 2022; 75 Cywes (R12-20240827) 1992; 216 Kim (R19-20240827) 2015; 12 Choi (R33-20240827) 2005; 579 Rovetto (R42-20240827) 1975; 37 Crowley (R29-20240827) 2016; 2016 Zhao (R36-20240827) 2020; 73 Xu (R16-20240827) 2017; 27 Murakami (R14-20240827) 2022; 82 Hirao (R1-20240827) 2022; 19 Adam (R5-20240827) 1992; 54 Zant (R50-20240827) 2016; 48 Dominissini (R21-20240827) 2013; 8 Xiang (R30-20240827) 2023; 10 Yu (R31-20240827) 2021; 53 Adam (R7-20240827) 1993; 25 Yang (R46-20240827) 2019; 104 Boudjema (R11-20240827) 1991; 28 Geng (R39-20240827) 2021; 58 Lee (R49-20240827) 2023; 40 Meng (R20-20240827) 2013; 29 Inomoto (R23-20240827) 1996; 61 Astarcioglu (R6-20240827) 1991; 23 Morgan (R10-20240827) 1991; 51 He (R15-20240827) 2021; 40 Wang (R22-20240827) 2019; 5 DiTullio (R27-20240827) 1974; 138 Zhang (R44-20240827) 2021; 6 Palombo (R8-20240827) 1989; 48 Xu (R17-20240827) 2022; 13 Kaufmann (R3-20240827) 2021; 406 Brooks (R24-20240827) 2018; 27 Shin (R32-20240827) 2012; 40 Chen (R45-20240827) 2021; 160 Dimicoli (R9-20240827) 1994; 107 Faitot (R25-20240827) 2018; 68 Bornaque (R47-20240827) 2022; 11 De Souza (R34-20240827) 2010; 588 Legouis (R40-20240827) 2020; 2 Li (R43-20240827) 2023; 10 Gou (R48-20240827) 2023; 133 Wiener (R35-20240827) 2021; 22 Zhou (R37-20240827) 2016; 44 Neely (R41-20240827) 1984; 55 Kondou (R38-20240827) 1992; 14 Klaunig (R18-20240827) 1981; 17 Zhai (R2-20240827) 2013; 10 Previs (R13-20240827) 2009; 29 Theodoraki (R26-20240827) 2006; 12 |
References_xml | – volume: 160 start-page: 1284 year: 2021 ident: R45-20240827 article-title: RNA N6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m6A-GLUT1-mTORC1 axis and is a therapeutic target publication-title: Gastroenterology doi: 10.1053/j.gastro.2020.11.013 contributor: fullname: Chen – volume: 14 start-page: 479 year: 1992 ident: R38-20240827 article-title: Alterations of gluconeogenesis by ischemic renal injury in rats publication-title: Ren Fail doi: 10.3109/08860229209047656 contributor: fullname: Kondou – volume: 13 start-page: 4555 year: 2022 ident: R17-20240827 article-title: Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a publication-title: Nat Commun doi: 10.1038/s41467-022-32169-4 contributor: fullname: Xu – volume: 58 start-page: 2309 year: 2021 ident: R39-20240827 article-title: Phosphoenolpyruvate carboxykinase (PCK) in the brain gluconeogenic pathway contributes to oxidative and lactic injury after stroke publication-title: Mol Neurobiol doi: 10.1007/s12035-020-02251-3 contributor: fullname: Geng – volume: 40 start-page: 11499 year: 2012 ident: R32-20240827 article-title: Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis publication-title: Nucleic Acids Res doi: 10.1093/nar/gks932 contributor: fullname: Shin – volume: 55 start-page: 816 year: 1984 ident: R41-20240827 article-title: Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts publication-title: Circ Res doi: 10.1161/01.RES.55.6.816 contributor: fullname: Neely – volume: 588 start-page: 2239 year: 2010 ident: R34-20240827 article-title: Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice publication-title: J Physiol doi: 10.1113/jphysiol.2009.183996 contributor: fullname: De Souza – volume: 12 start-page: 1825 year: 2006 ident: R26-20240827 article-title: Transhepatic lactate gradient in relation to liver ischemia/reperfusion injury during major hepatectomies publication-title: Liver Transplant doi: 10.1002/lt.20911 contributor: fullname: Theodoraki – volume: 40 start-page: e105977 year: 2021 ident: R15-20240827 article-title: m6 A RNA methylation: From mechanisms to therapeutic potential publication-title: EMBO J doi: 10.15252/embj.2020105977 contributor: fullname: He – volume: 17 start-page: 913 year: 1981 ident: R18-20240827 article-title: Mouse liver cell culture. I. Hepatocyte isolation publication-title: In Vitro doi: 10.1007/BF02618288 contributor: fullname: Klaunig – volume: 2 start-page: 732 year: 2020 ident: R40-20240827 article-title: Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality publication-title: Nat Metab doi: 10.1038/s42255-020-0238-1 contributor: fullname: Legouis – volume: 75 start-page: 338 year: 2022 ident: R28-20240827 article-title: Regulator of G-protein signaling 14 protects the liver from ischemia-reperfusion injury by suppressing TGF-β-activated kinase 1 activation publication-title: Hepatology doi: 10.1002/hep.32133 contributor: fullname: Zhang – volume: 133 start-page: e161713 year: 2023 ident: R48-20240827 article-title: Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression publication-title: J Clin Invest doi: 10.1172/JCI161713 contributor: fullname: Gou – volume: 216 start-page: 235 year: 1992 ident: R12-20240827 article-title: Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation publication-title: Ann Surg doi: 10.1097/00000658-199209000-00003 contributor: fullname: Cywes – volume: 138 start-page: 387 year: 1974 ident: R27-20240827 article-title: 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis publication-title: Biochem J doi: 10.1042/bj1380387 contributor: fullname: DiTullio – volume: 2016 start-page: pdb.prot087163 year: 2016 ident: R29-20240827 article-title: Measuring cell death by propidium iodide uptake and flow cytometry publication-title: Cold Spring Harb Protoc doi: 10.1101/pdb.prot087163 contributor: fullname: Crowley – volume: 10 start-page: 101 year: 2023 ident: R30-20240827 article-title: PCK1 dysregulation in cancer: Metabolic reprogramming, oncogenic activation, and therapeutic opportunities publication-title: Genes Dis doi: 10.1016/j.gendis.2022.02.010 contributor: fullname: Xiang – volume: 10 start-page: e2300436 year: 2023 ident: R43-20240827 article-title: Rna M6 a methylation regulates glycolysis of beige fat and contributes to systemic metabolic homeostasis publication-title: Adv Sci Weinh Baden-Wurtt Ger contributor: fullname: Li – volume: 48 start-page: 901 year: 1989 ident: R8-20240827 article-title: Glycolytic support of adenine nucleotides in rat liver flush-preserved with UW or Collins’ II. Importance of donor nutritional status publication-title: Transplantation doi: 10.1097/00007890-198912000-00002 contributor: fullname: Palombo – volume: 5 start-page: 30 year: 2019 ident: R22-20240827 article-title: Gluconeogenesis in cancer: Function and regulation of PEPCK, FBPase, and G6Pase publication-title: Trends Cancer doi: 10.1016/j.trecan.2018.11.003 contributor: fullname: Wang – volume: 27 start-page: 757 year: 2018 ident: R24-20240827 article-title: The science and translation of lactate shuttle theory publication-title: Cell Metab doi: 10.1016/j.cmet.2018.03.008 contributor: fullname: Brooks – volume: 51 start-page: 1176 year: 1991 ident: R10-20240827 article-title: Correlation of donor nutritional status with sinusoidal lining cell viability and liver function in the rat publication-title: Transplantation doi: 10.1097/00007890-199106000-00007 contributor: fullname: Morgan – volume: 406 start-page: 1 year: 2021 ident: R3-20240827 article-title: Mechanisms of nonalcoholic fatty liver disease and implications for surgery publication-title: Langenbecks Arch Surg doi: 10.1007/s00423-020-01965-1 contributor: fullname: Kaufmann – volume: 19 start-page: 239 year: 2022 ident: R1-20240827 article-title: Liver ischaemia-reperfusion injury: A new understanding of the role of innate immunity publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/s41575-021-00549-8 contributor: fullname: Hirao – volume: 23 start-page: 2465 year: 1991 ident: R6-20240827 article-title: High levels of glycogen in the donor liver improve survival after liver transplantation in rats publication-title: Transplant Proc contributor: fullname: Astarcioglu – volume: 29 start-page: 43 year: 2009 ident: R13-20240827 article-title: Is there glucose production outside of the liver and kidney? publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-080508-141134 contributor: fullname: Previs – volume: 579 start-page: 2795 year: 2005 ident: R33-20240827 article-title: Molecular mechanism of hypoxia-mediated hepatic gluconeogenesis by transcriptional regulation publication-title: FEBS Lett doi: 10.1016/j.febslet.2005.03.097 contributor: fullname: Choi – volume: 82 start-page: 2236 year: 2022 ident: R14-20240827 article-title: Hidden codes in mRNA: Control of gene expression by m6A publication-title: Mol Cell doi: 10.1016/j.molcel.2022.05.029 contributor: fullname: Murakami – volume: 27 start-page: 1100 year: 2017 ident: R16-20240827 article-title: Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation publication-title: Cell Res doi: 10.1038/cr.2017.100 contributor: fullname: Xu – volume: 11 start-page: 291 year: 2022 ident: R47-20240827 article-title: Glucose regulates m6A methylation of RNA in pancreatic islets publication-title: Cells doi: 10.3390/cells11020291 contributor: fullname: Bornaque – volume: 29 start-page: 1139 year: 1999 ident: R4-20240827 article-title: Ischemia-reperfusion injury in rat fatty liver: Role of nutritional status publication-title: Hepatology doi: 10.1002/hep.510290407 contributor: fullname: Caraceni – volume: 6 start-page: 377 year: 2021 ident: R44-20240827 article-title: m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-021-00699-w contributor: fullname: Zhang – volume: 37 start-page: 742 year: 1975 ident: R42-20240827 article-title: Mechanisms of glycolytic inhibition in ischemic rat hearts publication-title: Circ Res doi: 10.1161/01.RES.37.6.742 contributor: fullname: Rovetto – volume: 40 start-page: 1521 year: 2023 ident: R49-20240827 article-title: S-Adenosylmethionine: More than just a methyl donor publication-title: Nat Prod Rep doi: 10.1039/D2NP00086E contributor: fullname: Lee – volume: 12 start-page: 357 year: 2015 ident: R19-20240827 article-title: HISAT: A fast spliced aligner with low memory requirements publication-title: Nat Methods doi: 10.1038/nmeth.3317 contributor: fullname: Kim – volume: 10 start-page: 79 year: 2013 ident: R2-20240827 article-title: Ischaemia–reperfusion injury in liver transplantation—From bench to bedside publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/nrgastro.2012.225 contributor: fullname: Zhai – volume: 8 start-page: 176 year: 2013 ident: R21-20240827 article-title: Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing publication-title: Nat Protoc doi: 10.1038/nprot.2012.148 contributor: fullname: Dominissini – volume: 22 start-page: 119 year: 2021 ident: R35-20240827 article-title: The epitranscriptome beyond m6A publication-title: Nat Rev Genet doi: 10.1038/s41576-020-00295-8 contributor: fullname: Wiener – volume: 28 start-page: 227 year: 1991 ident: R11-20240827 article-title: Effects of method of preservation on functions of livers from fed and fasted rabbits publication-title: Cryobiology doi: 10.1016/0011-2240(91)90027-L contributor: fullname: Boudjema – volume: 73 start-page: 664 year: 2020 ident: R36-20240827 article-title: Epitranscriptomics in liver disease: Basic concepts and therapeutic potential publication-title: J Hepatol doi: 10.1016/j.jhep.2020.04.009 contributor: fullname: Zhao – volume: 48 start-page: 2709 year: 2016 ident: R50-20240827 article-title: Glucose metabolism and associated outcome after pediatric liver transplantation publication-title: Transplant Proc doi: 10.1016/j.transproceed.2016.08.013 contributor: fullname: Zant – volume: 25 start-page: 1536 year: 1993 ident: R7-20240827 article-title: Impact of glycogen content of the donor liver in clinical liver transplantation publication-title: Transplant Proc contributor: fullname: Adam – volume: 61 start-page: 869 year: 1996 ident: R23-20240827 article-title: Changes in glucose transporter 2 and carbohydrate-metabolizing enzymes in the liver during cold preservation and warm ischemia publication-title: Transplantation doi: 10.1097/00007890-199603270-00004 contributor: fullname: Inomoto – volume: 53 start-page: 101257 year: 2021 ident: R31-20240827 article-title: Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis publication-title: Mol Metab doi: 10.1016/j.molmet.2021.101257 contributor: fullname: Yu – volume: 104 start-page: 665 year: 2019 ident: R46-20240827 article-title: Glucose is involved in the dynamic regulation of m6A in patients with type 2 diabetes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2018-00619 contributor: fullname: Yang – volume: 68 start-page: 699 year: 2018 ident: R25-20240827 article-title: Impact of real-time metabolomics in liver transplantation: Graft evaluation and donor-recipient matching publication-title: J Hepatol doi: 10.1016/j.jhep.2017.11.022 contributor: fullname: Faitot – volume: 54 start-page: 753 year: 1992 ident: R5-20240827 article-title: The influence of the glycogen content of the donor liver on subsequent graft function and survival in rat liver transplantation publication-title: Transplantation doi: 10.1097/00007890-199210000-00043 contributor: fullname: Adam – volume: 107 start-page: 1764 year: 1994 ident: R9-20240827 article-title: A magnetic resonance study of the effect of nutritional status on cold-preserved murine liver publication-title: Gastroenterology doi: 10.1016/0016-5085(94)90819-2 contributor: fullname: Dimicoli – volume: 44 start-page: e91 year: 2016 ident: R37-20240827 article-title: SRAMP: Prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw104 contributor: fullname: Zhou – volume: 29 start-page: 1565 year: 2013 ident: R20-20240827 article-title: Exome-based analysis for RNA epigenome sequencing data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt171 contributor: fullname: Meng |
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Title | m6A-mediated gluconeogenic enzyme PCK1 upregulation protects against hepatic ischemia-reperfusion injury |
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