TRPV1-targeted ion-responsive hydrogel against pyroptosis of dry eye disease

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 499; p. 156155
• Main Authors: Ding, Xiangyu, Mu, Jingqing, Mi, Baoyue, Yuan, Zhengxi, Fang, Xiaolong, Ji, Xiaoyuan, Yuan, Xiaoyong, Guo, Shutao, Hua, Xia
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2024
• Subjects: Calcium signaling; Dry eye disease; In situ gelling system; Pyroptosis; Transient receptor potential vanilloid 1; Calcium signaling; Transient receptor potential vanilloid 1; Pyroptosis; In situ gelling system; Dry eye disease

[Display omitted] •Tear triggers in situ gelation of co-assembled nanofibers KFQ12/V1-Cal.•Hydrogel facilitates corneal wound healing and sustained drug release.•V1-Cal, an inhibitor of TRPV1 channel, is a potential agent for dry eye treatment.•TRPV1-Ca2+-Pyroptosis axis serves as a potential mechan...