Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APCMin/+ mice

• Published in: Biochemical and biophysical research communications Vol. 372; no. 1; pp. 249 - 253
• Main Authors: Elander, N., Ungerbäck, J., Olsson, H., Uematsu, S., Akira, S., Söderkvist, P.
• Format: Journal Article
• Language: English
• Published: 01.07.2008
• Subjects: 6-Ketoprostaglandin F1 alpha/analysis Animals Cell Transformation; MEDICIN; MEDICINE; Mut; Neoplastic/genetics/pathology Colorectal Neoplasms/genetics/pathology Dinoprostone/analysis/metabolism Female Gene Deletion Intramolecular Oxidoreductases/genetics Male Mice Mice

The induced synthesis of bioactive prostanoids downstream of cyclooxygenase-2 (COX-2) and prostaglandin H2 (PGH2) exerts a critical event in colorectal carcinogenesis. Here we demonstrate that APCMin/+ mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the...