A Possible Role of a Stress Hormone in Acne : Toll-like Receptor 2 Expression Is Enhanced by Glucocorticoids in Human Keratinocytes

• Published in: Journal of Society of Cosmetic Chemists of Japan Vol. 45; no. 3; pp. 199 - 206
• Main Authors: Shibata, Michio, Onodera, Tomoko, Kawai, Eriko, Hineno, Teruhiko
• Format: Journal Article
• Language: Japanese; English
• Published: The Society of Cosmetic Chemists of Japan 20.09.2011
• Subjects: acne; Cortisol; glucocorticoids; keratinocytes; Melia azadirachta; Propionibacterium acnes; stress hormone; TLR; TNF-α; Toll-like receptor

A link between psychosocial stress and acne has long been postulated, but its mechanism is not yet clear. Cortisol, the main glucocorticoid (GC) in humans, is considered a stress hormone. It is well known that GC treatment provokes an acneiform reaction. Toll-like receptor 2 (TLR2) activation by Pro...