Antcin A, a phytosterol regulates SARS‐CoV ‐2 spike protein‐mediated metabolic alteration in THP ‐1 cells explored by the 1 H‐NMR ‐based metabolomics approach

• Published in: Phytotherapy research Vol. 37; no. 3; pp. 885 - 902
• Main Authors: Dakpa, Gyaltsen, Senthil Kumar, Kanthasamy Jayabal, Tsao, Nai‐Wen, Wang, Sheng‐Yang
• Format: Journal Article
• Language: English
• Published: England 01.03.2023
• Subjects: COVID-19; COVID-19 Drug Treatment; Dexamethasone; Humans; Magnetic Resonance Spectroscopy; Phytosterols; SARS-CoV-2 - physiology; Spike Glycoprotein, Coronavirus - metabolism; THP-1 Cells; Taiwanofungus camphoratus; SARS-CoV-2 spike protein; 1H-NMR; antcin A; metabolomics

The mechanism of SARS‐CoV‐2 spike protein‐mediated perturbations of metabolic pathways and modulation of antcin A, a steroid‐like compound isolated from Taiwanofungus camphoratus , are not studied. Here, we investigated the metabolic alteration by SARS‐CoV‐2 spike protein and the regulatory effect o...