Intestinal Epithelial PTPN2 Restricts Adherent-Invasive E. coli Colonization and Promotes Anti-Microbial Peptide Responses in Mice

• Published in: The FASEB journal Vol. 36 Suppl 1
• Main Authors: Chatterjee, Pritha, Spalinger, Marianne, Shawki, Ali, Santos, Alina, Gries, Casey, Sayoc, Anica, Canale, Vinicus, Crawford, Meli'sa, Lei, Hillmin, Borneman, James, McCole, Declan
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022

In addition to a physical barrier, the intestinal epithelium generates a chemical barrier to the luminal microbiota by secreting various antimicrobial factors. Alterations in the gut microbiota and expansion of pathobionts such as adherent-invasive Escherichia coli (AIEC) are associated with inflamm...