Aortic Stiffness is Negatively Associated with Microvascular Glycocalyx Thickness and Microvascular Perfusion among Older Adults: Role of Carotid Pressure Pulsatility
The glycocalyx layer is essential to the maintenance of a healthy microvascular endothelium and diminishes with advancing age. Similarly, the aorta stiffens with aging and increases the risk of cardiovascular disease and target organ damage, possibly through pressure pulsatility-associated microvasc...
Saved in:
Published in | The FASEB journal Vol. 36 Suppl 1 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.05.2022
|
Online Access | Get more information |
Cover
Loading…
Abstract | The glycocalyx layer is essential to the maintenance of a healthy microvascular endothelium and diminishes with advancing age. Similarly, the aorta stiffens with aging and increases the risk of cardiovascular disease and target organ damage, possibly through pressure pulsatility-associated microvascular damage. However, whether aortic stiffness and/or pressure pulsatility are associated with microvascular endothelial glycocalyx structure/function among older adults is unknown. Therefore, the objective of this analysis was to investigate the potential relation between aortic stiffness and pressure pulsatility with glycocalyx thickness and microvascular perfusion in older adults. We hypothesized that increased aortic stiffness and pressure pulsatility would be associated with less glycocalyx thickness and microvascular perfusion in older adults.
Sublingual microvessels were assessed using intravital microscopy in older adults (n=24; age 61 ± 6y, 46% women). Perfused boundary region (PBR) and red blood cell (RBC) filling %, indirect indices of glycocalyx thickness (larger PBR=smaller thickness) and microvascular perfusion respectively, were determined in vessels between 5-25 µm RBC column width. Aortic stiffness was quantified by carotid-femoral pulse wave velocity (cfPWV) and carotid pressure pulsatility as carotid pulse pressure (PP)/mean arterial pressure (MAP).
Adjusting for age, sex and MAP, cfPWV was associated with larger PBR 5-25 (β: 0.08; p=0.001) and lower RBC filling % (β: -0.02, p=0.002). Higher carotid pressure pulsatility was associated with lower RBC filling % (β: -0.12; p=0.03), but this relation was attenuated after adjusting for sex (p=0.11). Upon stratification by sex, higher carotid pressure pulsatility was associated with larger PBR 5-25 (r=0.66, P=0.03) and lower RBC filling % (r=-0.73, P=0.01) in women, but not men (P=0.94 and P=0.77 respectively).
Higher aortic stiffness was negatively associated with microvascular glycocalyx thickness and microvascular perfusion among older adults. Additionally, carotid pressure pulsatility was negatively associated with glycocalyx thickness and microvascular perfusion in women only. The mechanisms that contribute to sex differences in the relation between pressure pulsatility and glycocalyx structure/function in older adults require further study. |
---|---|
AbstractList | The glycocalyx layer is essential to the maintenance of a healthy microvascular endothelium and diminishes with advancing age. Similarly, the aorta stiffens with aging and increases the risk of cardiovascular disease and target organ damage, possibly through pressure pulsatility-associated microvascular damage. However, whether aortic stiffness and/or pressure pulsatility are associated with microvascular endothelial glycocalyx structure/function among older adults is unknown. Therefore, the objective of this analysis was to investigate the potential relation between aortic stiffness and pressure pulsatility with glycocalyx thickness and microvascular perfusion in older adults. We hypothesized that increased aortic stiffness and pressure pulsatility would be associated with less glycocalyx thickness and microvascular perfusion in older adults.
Sublingual microvessels were assessed using intravital microscopy in older adults (n=24; age 61 ± 6y, 46% women). Perfused boundary region (PBR) and red blood cell (RBC) filling %, indirect indices of glycocalyx thickness (larger PBR=smaller thickness) and microvascular perfusion respectively, were determined in vessels between 5-25 µm RBC column width. Aortic stiffness was quantified by carotid-femoral pulse wave velocity (cfPWV) and carotid pressure pulsatility as carotid pulse pressure (PP)/mean arterial pressure (MAP).
Adjusting for age, sex and MAP, cfPWV was associated with larger PBR 5-25 (β: 0.08; p=0.001) and lower RBC filling % (β: -0.02, p=0.002). Higher carotid pressure pulsatility was associated with lower RBC filling % (β: -0.12; p=0.03), but this relation was attenuated after adjusting for sex (p=0.11). Upon stratification by sex, higher carotid pressure pulsatility was associated with larger PBR 5-25 (r=0.66, P=0.03) and lower RBC filling % (r=-0.73, P=0.01) in women, but not men (P=0.94 and P=0.77 respectively).
Higher aortic stiffness was negatively associated with microvascular glycocalyx thickness and microvascular perfusion among older adults. Additionally, carotid pressure pulsatility was negatively associated with glycocalyx thickness and microvascular perfusion in women only. The mechanisms that contribute to sex differences in the relation between pressure pulsatility and glycocalyx structure/function in older adults require further study. |
Author | Gimblet, Colin Guerrero, Mariah Pierce, Gary Armstrong, Matthew Nuckols, Virginia Stroud, Amy K |
Author_xml | – sequence: 1 givenname: Colin surname: Gimblet fullname: Gimblet, Colin organization: University of Iowa, Iowa City, IA – sequence: 2 givenname: Matthew surname: Armstrong fullname: Armstrong, Matthew organization: University of Iowa, Iowa City, IA – sequence: 3 givenname: Virginia surname: Nuckols fullname: Nuckols, Virginia organization: University of Iowa, Iowa City, IA – sequence: 4 givenname: Amy K surname: Stroud fullname: Stroud, Amy K organization: University of Iowa, Iowa City, IA – sequence: 5 givenname: Mariah surname: Guerrero fullname: Guerrero, Mariah organization: University of Iowa, Iowa City, IA – sequence: 6 givenname: Gary surname: Pierce fullname: Pierce, Gary organization: University of Iowa, Iowa City, IA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35553067$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkN1OwjAcxRujEUFfQfsCm-3Kus27hSiaoBDAa_JfP6BYVtJu6F7I55T4cePVufid_HJy-ui0drVC6IaSmJKC32oIqtrGCUmSmPF4QeM540V6gi5oykjEc056qB_ClhBCCeXnqMfS9Ih4doE-S-cbI_CiMVrXKgRsAn5Ra2jMQdkOlyE4YaBREr-bZoOfjfDuAEG0Fjwe2044Abb7wMuNEW_fAqjlv9pMed0G42oMO1ev8dRK5XEpW9uEOzx3VmGn8Qi8a4zEM3-0tF7hWWvDcYc1TXeJzjTYoK5-c4BeH-6Xo8doMh0_jcpJJGiSk0iTAjIAng4LQStaCUEKVaVJQfRQM82yIWhWVVmWKeBMJCzlHAopcy7zgkuZDND1j3ffVjslV3tvduC71d9hyRew7nSm |
ContentType | Journal Article |
Copyright | FASEB. |
Copyright_xml | – notice: FASEB. |
DBID | NPM |
DOI | 10.1096/fasebj.2022.36.S1.R3695 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1530-6860 |
ExternalDocumentID | 35553067 |
Genre | Journal Article |
GroupedDBID | --- -DZ -~X .55 0R~ 0VX 123 18M 1OB 1OC 29H 2WC 33P 34G 39C 3O- 4.4 53G 5GY 5RE 85S AAHHS AANLZ ABCUV ABDNZ ABEFU ABJNI ABOCM ACCFJ ACCZN ACGFS ACIWK ACNCT ACPOU ACPRK ACXQS ACYGS ADKYN ADZMN AEEZP AEIGN AENEX AEQDE AEUYR AFFNX AFFPM AFRAH AGCDD AHBTC AI. AITYG AIURR AIWBW AIZAD AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB BFHJK BIYOS C1A CS3 DCZOG DU5 D~5 E3Z EBS EJD F20 F5P F9R FRP H13 HGLYW HZ~ H~9 J5H L7B LATKE LEEKS MEWTI MVM NEJ NPM O9- OHT OVD Q-A RHF RHI RJQFR ROL SAMSI SJN SUPJJ TEORI TFA TR2 TWZ VH1 W8F WH7 WHG WOQ WXSBR X7M XJT XOL XSW Y6R YBU YCJ YHG YKV YNH YSK Z0Y ZCA ZE2 ZGI ZXP ~KM |
ID | FETCH-LOGICAL-c1280-f09a7aa6549c1b1bcc09eb5290f4f3f374af3bb777ea63c23566a9dd86d896dd2 |
IngestDate | Sat Sep 28 08:21:55 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Language | English |
License | FASEB. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c1280-f09a7aa6549c1b1bcc09eb5290f4f3f374af3bb777ea63c23566a9dd86d896dd2 |
PMID | 35553067 |
ParticipantIDs | pubmed_primary_35553067 |
PublicationCentury | 2000 |
PublicationDate | 2022-May |
PublicationDateYYYYMMDD | 2022-05-01 |
PublicationDate_xml | – month: 05 year: 2022 text: 2022-May |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The FASEB journal |
PublicationTitleAlternate | FASEB J |
PublicationYear | 2022 |
SSID | ssj0001016 |
Score | 2.43688 |
Snippet | The glycocalyx layer is essential to the maintenance of a healthy microvascular endothelium and diminishes with advancing age. Similarly, the aorta stiffens... |
SourceID | pubmed |
SourceType | Index Database |
Title | Aortic Stiffness is Negatively Associated with Microvascular Glycocalyx Thickness and Microvascular Perfusion among Older Adults: Role of Carotid Pressure Pulsatility |
URI | https://www.ncbi.nlm.nih.gov/pubmed/35553067 |
Volume | 36 Suppl 1 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECWcFi1yKbrvxRx6M6TKlkRJvblB0qBA06JOgNwCkiINJbIdeAGqflD_o3_WGVKSFSNBl4sgkBJhcR6GM-NHPsbeStoOqXnkSRnGHnlJT3AZeErR4d5KBKm0BNkjfngSfTqNT3u9Xx3W0nolffXj2n0l_2NVbEO70i7Zf7BsOyg24D3aF69oYbz-lY1Hc2rDgLEwxrqsgrzWxJ7lXVbt1DcM889Evmuppx_LStFCVn0n8U51YQewtIsrj33VC7NeWtKy1SX6QrLe_REd2-HYdDU9kZgjqyKv9xsuiAhUElOIwvxuBEy4PBiN9z_0u59IDKBiKkv318geKQl1oLikev3EbS2y8uRtCXutLualE3QvFpNiVrSrzBjfWbui-bSqi7l1dQMT45ZL6OvGI2N-mzrRgcZlh7xvRU_7g2tXAUzLyHQYBshzn0b1Q-6PB_63kDtFzw42LqcWHBh2xZQ9_bl363jupmuH7SQpaYccUbmoDgWoNNKQCjP-7oZftMvuNqNsJTc2yDm-z-7V2QmMHNQesJ6ePWR3nF5p9Yj9dICDFnBQLGEDONgADghwcAVJsAEctIADBNzWYy3gwAIOLODAAe49ENxgbqCGGzRwgw7cHrOTg_3jvUOvFvrwFIZHgWeCTCRC8DjK1EAOpFJBpmU8zAITmdCESSRMKGWSJFrwUA1DzEFElucpz9OM5_nwCbs1m8_0MwZ6KPNBbKI80CqKpJQYoUe47shEBAJvnrOnboLPLt1pLmfN1L-4secl291A8xW7bdB96NcYi67kG2vv35znkaY |
link.rule.ids | 780 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aortic+Stiffness+is+Negatively+Associated+with+Microvascular+Glycocalyx+Thickness+and+Microvascular+Perfusion+among+Older+Adults%3A+Role+of+Carotid+Pressure+Pulsatility&rft.jtitle=The+FASEB+journal&rft.au=Gimblet%2C+Colin&rft.au=Armstrong%2C+Matthew&rft.au=Nuckols%2C+Virginia&rft.au=Stroud%2C+Amy+K&rft.date=2022-05-01&rft.eissn=1530-6860&rft.volume=36+Suppl+1&rft_id=info:doi/10.1096%2Ffasebj.2022.36.S1.R3695&rft_id=info%3Apmid%2F35553067&rft_id=info%3Apmid%2F35553067&rft.externalDocID=35553067 |