Highly efficient Cu(acac)2 catalyzed multi component synthesis of 1,4-disubstituted-1,2,3-triazoles using aryl halide/ phenyl boronic acid or styrene oxide and aryl alkynes with sodium azide in aqueous medium

• Published in: Tetrahedron Vol. 179; p. 134629
• Main Authors: Pappula, Upendra, Kalyana, Venkata Prasad, Roy, Ujjal Kanti
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2025
• Subjects: 1,4-Disubstituted-1,2,3-triazoles; alkynes; Aryl halide activation; boronic acids; catalysts; catalytic activity; Copper catalyst; Cycloaddition; cycloaddition reactions; sodium azide; styrene; β-Hydroxy-triazoles; 1,4-Disubstituted-1,2,3-triazoles; Aryl halide activation; Cycloaddition; β-Hydroxy-triazoles; Copper catalyst

The sequential three-component reaction of aryl halide/phenyl boronic acid or styrene oxide, with sodium azide and alkynes using copper catalysis has been discussed. The reaction proceeds via the in-situ generation of aryl azide/azido-alcohol followed by synthesis of 1,4-disubstituted-1,2,3-triazole...