ChemInform Abstract: Rhodium-Catalyzed Enantioselective Hydrogenation of Tetrasubstituted α-Acetoxy β-Enamido Esters: A New Approach to Chiral α-Hydroxyl-β-amino Acid Derivatives

The methodology provides valuable building blocks for the synthesis of biologically active compounds which is exemplified by the transformation of one product into the corresponding α‐hydroxy‐β‐amino acid, an intermediate of the taxol side chain.

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Bibliographic Details
Published inChemInform Vol. 46; no. 21; p. no
Main Authors Wang, Qingli, Huang, Wenhua, Yuan, Haoquan, Cai, Qin, Chen, Liming, Lv, Hui, Zhang, Xumu
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.05.2015
WILEY‐VCH Verlag
Subjects
aminocarboxylic acids (hydrazinocarboxylic acids) and esters (benzene compounds)
catalysis
catalysis, phase‐transfer catalysis
diastereoselective syntheses
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism)
enantioselective syntheses (incl. cis/trans-isomerism)
hydrogenation
phase-transfer catalysis
reduction
reduction, hydrogenation
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Summary:The methodology provides valuable building blocks for the synthesis of biologically active compounds which is exemplified by the transformation of one product into the corresponding α‐hydroxy‐β‐amino acid, an intermediate of the taxol side chain.
Bibliography:ark:/67375/WNG-DX2GNRNZ-N
ArticleID:CHIN201521076
istex:8D6029D4874F6565311C8820CFFB3F1F188E1FD5
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201521076