β1-subunit–induced structural rearrangements of the Ca 2+ - and voltage-activated K + (BK) channel

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 23
• Main Authors: Castillo, Juan P., Sánchez-Rodríguez, Jorge E., Hyde, H. Clark, Zaelzer, Cristian A., Aguayo, Daniel, Sepúlveda, Romina V., Luk, Louis Y. P., Kent, Stephen B. H., Gonzalez-Nilo, Fernando D., Bezanilla, Francisco, Latorre, Ramón
• Format: Journal Article
• Language: English
• Published: 07.06.2016

Large-conductance Ca 2+ - and voltage-activated K + (BK) channels play many physiological roles, ranging from the maintenance of smooth muscle tone to the modulation of alcohol tolerance. In most cases, this physiological versatility of the BK channel is due to the association of the pore-forming α-...