Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIA Glc

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 8; pp. 2407 - 2412
• Main Authors: Hariharan, Parameswaran, Balasubramaniam, Dhandayuthapani, Peterkofsky, Alan, Kaback, H. Ronald, Guan, Lan
• Format: Journal Article
• Language: English
• Published: 24.02.2015

Carbohydrate uptake in many bacteria is regulated by the phosphotransferase protein IIA Glc , enabling cells to use glucose preferentially over other sugars. Lactose permease (LacY) is one of many sugar permeases regulated by IIA Glc , but the mechanism of inducer exclusion is unclear. We now show b...