Gastroretentive drug delivery system: An Overview

Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before i...

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Published inInternational journal of pharmaceutical dosage forms and technology Vol. 16; no. 1; pp. 91 - 97
Main Authors Rathor, Muskan, Garg, Anshika
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 22.02.2024
Subjects
Bioavailability
Drug delivery systems
Drug dosages
Hydrogels
Patient compliance
Pharmaceuticals
Physiology
Polymers
Retention
Small intestine
Stomach
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Abstract Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.
AbstractList [...]the 6 disappointment of traditional medication delivery system to hold drugs in the stomach may prompt the improvement of GRDDS. The fundamental motivation behind this is to give data on different GRDDS that have been created to date, just as the physiological condition of the stomach, appropriate medication candidate for GRDDS, factors influencing GRDDS, and in vitro and in vivo characterization of GRDDS2. [...]scintigraphic considers including estimations of gastric emptying rates in healthy person subjects have uncovered that few physiological issues for example, inability to restrain and find the medication delivery system inside the ideal area of the GIT and the eccentric gastric exhausting time (around 8-12hrs) variable gastric motility makes the significant amount of medication be unabsorbed. [...]it is more attractive to design a controlled release drug delivery system (CRDDS) with broadened GIT residence time and medication release free of tolerant related factors, for example, age, race, sex, food dietary patterns and illness states, as they could truly influence the arrival of a medication from the CRDDS. [...]they are valuable in the treatment of issues identified with stomach and small intestine.
Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.
Author Rathor, Muskan
Garg, Anshika
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Snippet Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can...
[...]the 6 disappointment of traditional medication delivery system to hold drugs in the stomach may prompt the improvement of GRDDS. The fundamental...
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SubjectTerms Bioavailability
Drug delivery systems
Drug dosages
Hydrogels
Patient compliance
Pharmaceuticals
Physiology
Polymers
Retention
Small intestine
Stomach
Title Gastroretentive drug delivery system: An Overview
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Volume 16
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