Development of [ 18 F]AmBF 3 Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [ 18 F]AmBF 3 -PEG 7 -Tyr 3 -Octreotide in an AR42J Pancreatic Carcinoma Model

• Published in: Bioconjugate chemistry Vol. 33; no. 7; pp. 1393 - 1404
• Main Authors: Otaru, Sofia, Paulus, Andreas, Imlimthan, Surachet, Kuurne, Iida, Virtanen, Helena, Liljenbäck, Heidi, Tolvanen, Tuula, Auchynnikava, Tatsiana, Roivainen, Anne, Helariutta, Kerttuli, Sarparanta, Mirkka, Airaksinen, Anu J.
• Format: Journal Article
• Language: English
• Published: United States 20.07.2022
• Subjects: Animals; Cell Line, Tumor; Fluorine Radioisotopes - chemistry; Heterocyclic Compounds; Mice; Mice, Nude; Octreotide; Pancreatic Neoplasms; Polyethylene Glycols; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography - methods; Radiopharmaceuticals - chemistry; Rats; Tissue Distribution

Radiolabeled peptides have emerged as highly specific agents for targeting receptors expressed in tumors for therapeutic and diagnostic purposes. Peptides developed for positron emission tomography (PET) are typically radiolabeled using prosthetic groups or bifunctional chelators for fast "kit-...