Combined Effects of Corticosteroids and Antiglaucoma Drugs on Corneal Epithelium

Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The results indicate significantly reduced resistance of cultured epithelial cells to a combination of corticosteroids and antiglaucoma drugs. The st...

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Published inOphthalmic research Vol. 5; no. 3; pp. 186 - 192
Main Authors Krejčí, L., Krejčová, H.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 09.12.2009
Subjects
Pharmacodynamics
Corneal epithelium
Corticosteroids
Antiglaucoma drugs
Tissue culture
Degeneration
Time factor
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Abstract Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The results indicate significantly reduced resistance of cultured epithelial cells to a combination of corticosteroids and antiglaucoma drugs. The strongest cytotoxic effects were produced in the epithelial cultures pretreated with antiglaucoma drugs and consequently exposed to the combined therapy with prednisolone and antiglaucoma drugs. Neostigmine was found to have a most deleterious effect on corneal cells in tissue culture.
AbstractList Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The results indicate significantly reduced resistance of cultured epithelial cells to a combination of corticosteroids and antiglaucoma drugs. The strongest cytotoxic effects were produced in the epithelial cultures pretreated with antiglaucoma drugs and consequently exposed to the combined therapy with prednisolone and antiglaucoma drugs. Neostigmine was found to have a most deleterious effect on corneal cells in tissue culture.
Author Krejčí, L.
Krejčová, H.
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Issue 3
Keywords Pharmacodynamics
Corneal epithelium
Corticosteroids
Antiglaucoma drugs
Tissue culture
Degeneration
Time factor
Language English
License Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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Snippet Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The...
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Title Combined Effects of Corticosteroids and Antiglaucoma Drugs on Corneal Epithelium
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