Combined Effects of Corticosteroids and Antiglaucoma Drugs on Corneal Epithelium

Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The results indicate significantly reduced resistance of cultured epithelial cells to a combination of corticosteroids and antiglaucoma drugs. The st...

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Bibliographic Details
Published inOphthalmic research Vol. 5; no. 3; pp. 186 - 192
Main Authors Krejčí, L., Krejčová, H.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 09.12.2009
Subjects
Pharmacodynamics
Corneal epithelium
Corticosteroids
Antiglaucoma drugs
Tissue culture
Degeneration
Time factor
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Summary:Tissue culture methods were used to study the combined effects of topical corticosteroids and various antiglaucoma drugs on normal corneal epithelium. The results indicate significantly reduced resistance of cultured epithelial cells to a combination of corticosteroids and antiglaucoma drugs. The strongest cytotoxic effects were produced in the epithelial cultures pretreated with antiglaucoma drugs and consequently exposed to the combined therapy with prednisolone and antiglaucoma drugs. Neostigmine was found to have a most deleterious effect on corneal cells in tissue culture.
ISSN:0030-3747
1423-0259
DOI:10.1159/000266037