Isoelectric Focusing Studies of Human Red Cell PGM, in Japanese, with Special Reference to the Characterization of PGM17

The distribution of phosphoglucomutase (PGM,) subtypes in human red cells was determined by isoelectric focusing in 218 Japanese samples. Nine common phenotypes were observed corresponding to the following frequencies of the four alleles at the PGM 1 locus: PGM 1 1+ 0.6560, PGM 1 1– 0.1170, PGM 1 2+...

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Bibliographic Details
Published inHuman heredity Vol. 32; no. 5; pp. 301 - 307
Main Authors Nishigaki, I., Benkmann, H.-G., Goedde, H.W.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 29.08.2008
Subjects
Original Paper
Japanese sample
Isoelectric focusing
PGM17 allele
Phosphoglucomutase
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Summary:The distribution of phosphoglucomutase (PGM,) subtypes in human red cells was determined by isoelectric focusing in 218 Japanese samples. Nine common phenotypes were observed corresponding to the following frequencies of the four alleles at the PGM 1 locus: PGM 1 1+ 0.6560, PGM 1 1– 0.1170, PGM 1 2+ 0.1674 and PGM 1 2– 0.0505. In addition, a characterization of the PGM 1 7 sallele was performed. Our results obtained in the present study revealed the possibility that the PGM 1 7 allele may be differentiated in the two alleles of PGM 1 7+ and PGM 1 7– through an investigation of isoelectric focusing.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153316