The Effect of Astaxanthin on Ochratoxin A-Induced Intestinal Injury in Chickens Through RIPK1/RIPK3/MLKL Pathway

• Published in: Antioxidants Vol. 14; no. 8; p. 915
• Main Authors: Fan, Ruiwen, Tian, Wenqi, Jin, Bo, Sun, Yuhang, Long, Miao, Yang, Shuhua, Li, Peng
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 25.07.2025; MDPI
• Subjects: Antioxidants; Apoptosis; Astaxanthin; Bioaccumulation; Bioengineering; Biotechnology; Cell culture; Cell death; Endoplasmic reticulum; Epithelial cells; Feed additives; Feeds; Heat resistance; Inflammation; Kidneys; Kinases; Laboratory animals; Necroptosis; Ochratoxin A; Oxidative stress; Phosphorylation; Poultry; Signal transduction; Small intestine; Toxicity; Toxins; Zonula occludens-1 protein; Beijing China; United States > US; China; Shanghai China

Ochratoxin A (OTA), as a mycotoxin, can contaminate a variety of feeds and foods. Existing studies have shown that the main toxicity of OTA to organisms is nephrotoxicity, but the toxic mechanism to other organs is still worthy of further study. Whether OTA causes intestinal damage through the necro...