Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial

• Published in: BMJ open Vol. 14; no. 11; p. e091059
• Main Authors: Yang, Xinguang, He, Xiongjun, Pan, Dong, Xu, Yongteng, Peng, Huiyuan, Li, Kaifeng, Zhang, Min, Zhu, Yingying, Chen, Yanting, He, Baixuan, Zhou, Hongxing, Li, Jie, Hou, Hongbiao, Sun, Haoyang, Liu, Yajie, Tang, Yamei
• Format: Journal Article
• Language: English
• Published: 05.11.2024

Introduction Successful reperfusion does not always lead to good neurological outcomes and impaired microcirculation can be one of the underlying causes. Intra-arterial alteplase after mechanical thrombectomy (MT) may improve microcirculation contributing to neurological recovery, but prospective ra...