P0943FAT MASS/FAT FREE MASS RATIO AS A CARDIOVASCULAR RISK FACTOR. SURVIVAL STUDY

• Published in: Nephrology, dialysis, transplantation Vol. 35; no. Supplement_3
• Main Authors: Barril, Guillermina, Nogueira, Angel, Garcia, Nuria, Sanz, Paloma, Alvarez, Graciela, Gil Giraldo, Leydy Yohana, Muñoz, Patricia, Giorgi, Martin, Nuñez, Almudena, Sanchez Tomero, Jose Antonio
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.06.2020
• DOI: 10.1093/ndt/gfaa142.P0943
• ISSN: 0931-0509

Abstract Background and Aims Excess fat mass correlates with cardiovascular risk and if the increase in BMI is at the expense of fat mass it can increase mortality. Aims- To evaluate the Fat Mass/Fat Free Mass ratio (FM/FFM)in 195 CKD patients and establish a correlation with nutrition-inflammation parameters, body composition and hand grip strenght Method We have studied 195 patients aged 67.01 ± 14.52 years, 126 (64.6%) men and 69 (35.4%) women. 41% in HD and 59% with advanced CKD. We have determined FM/FFM ratio using BIA monofrequency Bodigram Plus (Akhern) and hand grip stengh ( baseline).We determine biochemical nutrition-inflammation parameters also. Results xRatio FM/FFM = 0.499 ± 0.2304, in men = 0.41 ± 0.16 and in women = 0.64 ± 0.26 (both less than published 0.57 men and 0.867 in women). Median 0.4558 and percentils (p) with cut-off points 0.3868 and 0.5574. In HD 31 in P1, 23 in P2 and 26 in P3. In advanced CKD 32 in P1, 41 in P2 and 42 in P3. Anova significant according to percentiles: SMI, age, TBW% BCMI, albumin, waist circunference, and Hand grip strenght. Correlations Men FM / FFM ratio direct sig correlation with weight, AEC% and Trasferrin%, inverse with MIS, SMI, Na / K, BCM%, TBW%, IBW%, BCMI and right dynamometry. Do not continue with BMI, Phase Angle, Hb, lymphocytes, prealbumin, PCR. Women FM/FFM ratio direct sig correlation wih: weight, Na / k, BMI, prealbumin, CRP, MIS, inverse with: TBW. No sig: SMI, BCM%, EBW%, IBW%, MAMC, BCMI, Hb, hand grip strenght, lymphocytes or transferrin. In the 24-month mortality study we found no significant differences in Kaplan Meier overall mortality using the 3 percentiles. They died 7/63 in P1, 1/64 in P2 and 8/68 in P3. If we make the union of 1 and 2 vs percentil3 we find significant differences in mortality between strata, especially in HD with Long Rank 0.05. Conclusions 1.-The FM /FFM ratio is a useful tool for diagnosis of sarcopenic obesity 2.-It correlates significantly with parameters of CRP (direct) inflammation, muscle strength (inverse) and CV risk (direct waist circumference and tricipital fold) 3.- In a survival study joining P1 + P2 vs P3 we found greater survival in P1 + P2, mainly in HD. Figure: Kaplan Meier curves in HD and ACKD patients