2157. Phase 1 Study in Healthy Chinese Subjects of Novel Prodrug, MRX-4

• Published in: Open forum infectious diseases Vol. 10; no. Supplement_2
• Main Authors: Yang, Haijing, Li, Size, Wang, Hailin, Cao, Guoying, Zhang, Jing
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 27.11.2023

Abstract Background MRX-4 is a prodrug of contezolid (MRX-1), a new oxazilidone approved in China. We evaluated the safety and pharmacokinetic (PK) profile of IV and oral MRX-4 and its metabolites. Methods This randomized, double-blind, placebo-controlled study was conducted at Huashan Hospital, (Sh...