Modification of 4-Fold and B-Pores in Bacterioferritin from Mycobacterium tuberculosis Reveals Their Role in Fe 2+ Entry and Oxidoreductase Activity

• Published in: Inorganic chemistry Vol. 62; no. 1; pp. 178 - 191
• Main Authors: Parida, Akankshika, Mohanty, Abhinav, Raut, Rohit Kumar, Padhy, Ipsita, Behera, Rabindra K.
• Format: Journal Article
• Language: English
• Published: United States 09.01.2023
• Subjects: Ceruloplasmin - chemistry; Ferritins - chemistry; Iron - chemistry; Mycobacterium tuberculosis - metabolism; Oxidation-Reduction; Oxidoreductases - metabolism

The self-assembled ferritin nanocages, nature's solution to iron toxicity and its low solubility, scavenge free iron to synthesize hydrated ferric oxyhydroxide mineral inside their central cavity by protein-mediated ferroxidase and hydrolytic/nucleation reactions. These complex processes in fer...