Neutral Ligands as Potential 64 Cu Chelators for Positron Emission Tomography Imaging Applications in Alzheimer's Disease

• Published in: Inorganic chemistry Vol. 61; no. 11; pp. 4778 - 4787
• Main Authors: Huang, Yiran, Huynh, Truc T, Sun, Liang, Hu, Chi-Herng, Wang, Yung-Ching, Rogers, Buck E, Mirica, Liviu M
• Format: Journal Article
• Language: English
• Published: United States 21.03.2022
• Subjects: Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Animals; Chelating Agents - chemistry; Ligands; Mice; Plaque, Amyloid; Positron-Emission Tomography - methods; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacology

Positron emission tomography (PET), which uses positron-emitting radionuclides to visualize and measure processes in the human body, is a useful noninvasive diagnostic tool for Alzheimer's disease (AD). The development of longer-lived radiolabeled compounds is essential for further expansion of...