Association between transient tachypnea of newborn and bronchiolitis development

Purpose: Transient tachypnea of newborn (TTN) is characterized by inadequate absorption of fetal lung fluid. While typically benign and self-limiting, TTN may be associated with an increased risk of wheezing syndromes. This study aimed to investigate the association between TTN and the development o...

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Published inAllergy asthma & respiratory disease Vol. 13; no. 3; pp. 92 - 95
Main Authors Brelopes, Sonia Alia, Kang, Eun Kyeong
Format Journal Article
LanguageEnglish
Published 대한 소아알레르기 호흡기학회 01.07.2025
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ISSN2288-0402
2288-0410
DOI10.4168/aard.2025.13.3.92

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Abstract Purpose: Transient tachypnea of newborn (TTN) is characterized by inadequate absorption of fetal lung fluid. While typically benign and self-limiting, TTN may be associated with an increased risk of wheezing syndromes. This study aimed to investigate the association between TTN and the development of bronchiolitis within the first 2 years of life. Methods: A retrospective cohort study included 184 newborns with TTN and 213 healthy controls, all born between January 1, 2006, and December 31, 2019. Medical records were analyzed for demographics, bronchiolitis incidence, and viral etiology. Results: The incidence of bronchiolitis was significantly higher in the TTN group (29.3%) than in the healthy controls (14.1%) (P<0.01). TTN was identified as an independent risk factor for bronchiolitis (odds ratio, 2.44; 95% confidence interval, 1.45–4.11). Conclusion: TTN may be a potential risk factor for bronchiolitis development. Further research is needed to clarify the possible association and underlying mechanisms linking TTN and bronchiolitis. KCI Citation Count: 0
AbstractList Purpose: Transient tachypnea of newborn (TTN) is characterized by inadequate absorption of fetal lung fluid. While typically benign and self-limiting, TTN may be associated with an increased risk of wheezing syndromes. This study aimed to investigate the association between TTN and the development of bronchiolitis within the first 2 years of life. Methods: A retrospective cohort study included 184 newborns with TTN and 213 healthy controls, all born between January 1, 2006, and December 31, 2019. Medical records were analyzed for demographics, bronchiolitis incidence, and viral etiology. Results: The incidence of bronchiolitis was significantly higher in the TTN group (29.3%) than in the healthy controls (14.1%) (P<0.01). TTN was identified as an independent risk factor for bronchiolitis (odds ratio, 2.44; 95% confidence interval, 1.45–4.11). Conclusion: TTN may be a potential risk factor for bronchiolitis development. Further research is needed to clarify the possible association and underlying mechanisms linking TTN and bronchiolitis. KCI Citation Count: 0
Author Brelopes, Sonia Alia
Kang, Eun Kyeong
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  organization: Department of Pediatrics, Dongguk University Medical Center, Goyang, Korea
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Title Association between transient tachypnea of newborn and bronchiolitis development
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