Dithiocarbazate–Fe III , −Co III , −Ni II , and −Zn II Complexes: Design, Synthesis, Structure, and Anticancer Evaluation

Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe (L) ]·Cl·2H O , [Co (L) ]·NO ·2.5H O , [Ni (L) ] , and [Zn (L) ] , have been designed and evaluated for their efficacy as antineoplastic agents. Among the...

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Published inJournal of medicinal chemistry Vol. 65; no. 9; pp. 6677 - 6689
Main Authors Gou, Yi, Jia, Xiaoying, Hou, Li Xia, Deng, Jun Gang, Huang, Guo Jin, Jiang, Hao Wen, Yang, Feng
Format Journal Article
LanguageEnglish
Published United States 12.05.2022
Online AccessGet full text
ISSN0022-2623
1520-4804
DOI10.1021/acs.jmedchem.1c02186

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Abstract Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe (L) ]·Cl·2H O , [Co (L) ]·NO ·2.5H O , [Ni (L) ] , and [Zn (L) ] , have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex exhibited higher anticancer efficacy than complexes , , , and platin against several cancer cell lines. Hemolysis assays revealed that complex showed comparable hemolysis with platin. anticancer evaluations showed that complex could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.
AbstractList Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe (L) ]·Cl·2H O , [Co (L) ]·NO ·2.5H O , [Ni (L) ] , and [Zn (L) ] , have been designed and evaluated for their efficacy as antineoplastic agents. Among them, complex exhibited higher anticancer efficacy than complexes , , , and platin against several cancer cell lines. Hemolysis assays revealed that complex showed comparable hemolysis with platin. anticancer evaluations showed that complex could retard tumor xenograft growth effectively with low systemic toxicity. Further studies revealed that complex suppressed cancer cells by triggering multiple mechanisms involving the simultaneous inhibition of mitochondria and glycolytic bioenergetics. Overall, our study provides new insights into the anticancer mechanism of Co complexes, which can be used as a good strategy to overcome the flexibility of cancer cells to chemotherapy adaptation.
Author Jiang, Hao Wen
Deng, Jun Gang
Huang, Guo Jin
Gou, Yi
Hou, Li Xia
Jia, Xiaoying
Yang, Feng
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  organization: Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Norma University, Guilin 541004, Guangxi, China
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Snippet Non-platinum-metal complexes show great potential as anticancer agents. Herein, a series of dithiocarbazate non-Pt-metal complexes, including [Fe (L) ]·Cl·2H O...
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Title Dithiocarbazate–Fe III , −Co III , −Ni II , and −Zn II Complexes: Design, Synthesis, Structure, and Anticancer Evaluation
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