The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats

• Published in: bioRxiv
• Main Authors: Makhijani, Viren H, Franklin, Janay P, Kalynn Van Voorhies, tino, Brayden, Besheer, Joyce
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.01.2020
• Subjects: Alcohol; Amygdala; Animal behavior; Anxiety; c-Fos protein; Corticosterone; Drug self-administration; Experiments; Habituation; Neurobiology; Odor; Post traumatic stress disorder; Prefrontal cortex; Trimethylthiazoline

Post-traumatic stress disorder (PTSD) is a psychiatric illness that can increase the risk for developing an alcohol use disorder (AUD). While clinical data has been useful in identifying similarities in the neurobiological bases of these disorders, preclinical models are essential for understanding...