Dynamic Resting State Motor Network Connectivity of Neurotypical Children, the Groundwork for Network-Guided Therapy in Childhood Movement Disorders

• Published in: bioRxiv
• Main Authors: Sussman, Bethany L, Wyckoff, Sarah N, Fine, Justin M, Heim, Jennifer, Wilfong, Angus A, Adelson, P David, Kruer, Michael C, Boerwinkle, Varina L
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 02.12.2021
• Subjects: Basal ganglia; Bayesian analysis; Brain mapping; Cerebellum; Children; Connectivity; Cortex (motor); Functional magnetic resonance imaging; Globus pallidus; Hemispheric laterality; Mathematical models; Movement disorders; Neostriatum; Neural networks; Pediatrics; Subthalamic nucleus; Thalamus

Background: Normative childhood motor network resting-state fMRI effective connectivity is undefined, yet necessary for translatable dynamic resting-state network informed treatments in pediatric movement disorders. Method: Cross-spectral dynamic causal modelling of resting-state fMRI was investigat...