Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 by Upregulating Hyaluronan via NamiRNA-Enhancer Network

• Published in: bioRxiv
• Main Authors: Li, Wei, Yang, Shuai, Xu, Peng, Zhang, Dapeng, Tong, Ying, Chen, Lu, Jia, Ben, Ang, Li, Daoping Ru, Zhang, Baolong, Liu, Mengxing, Cheng, Lian, Chen, Cancan, Fu, Weihui, Yuan, Songhua, Ren, Xiaoguang, Liang, Ying, Yang, Zhicong, Li, Wenxuan, Wang, Shaoxuan, Zhang, Xiaoyan, Lu, Hongzhou, Xu, Jianqing, Wang, Hailing, Yu, Wenqiang
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 05.11.2020
• Subjects: ACE2; Angiotensin-converting enzyme 2; Coronaviruses; COVID-19; Cytokine storm; Cytokines; Drug development; Genomes; Hyaluronan synthase; Hyaluronic acid; Patients; Respiratory distress syndrome; Severe acute respiratory syndrome coronavirus 2

ACE2), a well-known cell entry receptor of SARS-CoV-2, and hyaluronan synthase 2 (HAS2), which further increases hyaluronan formation. Noteworthily, hyaluronan level in plasma of COVID-19 patients is tightly correlated with severity and high risk for acute respiratory distress syndrome (ARDS) and ma...