Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

• Published in: bioRxiv
• Main Authors: Wu, Liang, Yan, Jiayan, Bai, Yinqi, Chen, Feiyu, Xu, Jiangshan, Zou, Xuanxuan, Huang, Ao, Hou, Liangzhen, Yu, Zhong, Zehua Jing, Zhou, Xiaorui, Sun, Haixiang, Cheng, Mengnan, Ji, Yuan, Luo, Rongkui, Li, Qinqin, Wang, Pengxiang, Guo, Dezhen, Huang, Waidong, Lei, Junjie, Liao, Sha, Li, Yuxiang, Jiang, Zhifeng, Yao, Na, Yang, Yu, Yao, Li, Liu, Fengming, Zhang, Mingyuan, Yang, Huanming, Yang, Shuang, Xu, Xun, Liu, Longqi, Wang, Xiangdong, Wang, Jian, Fan, Jia, Liu, Shiping, Yang, Xinrong, Chen, Ao, Zhou, Jian
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 22.10.2021
• Subjects: Amyloid; Cholangiocarcinoma; Hepatocellular carcinoma; Hepatocytes; Invasiveness; Macrophages; Metastases; Solid tumors; Spatial heterogeneity; Tumor cells; Tumor microenvironment; Tumors

Solid tumors are complex ecosystems, and heterogeneity is the major challenge for overcoming tumor relapse and metastasis. Uncovering the spatial heterogeneity of cell types and functional states in tumors is essential for developing effective treatment, especially in invasive fronts of tumor, the m...