Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes

• Published in: bioRxiv
• Main Authors: Ware, Kathryn E, Gupta, Santosh, Eng, Jared, Kemeny, Gabor, Puviindran, Bhairavy J, Wen-Chi, Foo, Crawford, Lorin A, R Garland Almquist, Runyambo, Daniella, Thomas, Beatrice C, Sheth, Maya U, Agarwal, Anika, Pierobon, Mariaelena, Petricoin, Emanueel F, Corcoran, David L, Freedman, Jennifer, Patierno, Steven R, Zhang, Tian, Simon, Gregory, Sychev, Zoi, Drake, Justin M, Armstrong, Andrew J, Somarelli, Jason
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.04.2020
• Subjects: Endocrine therapy; Inventors; MAP kinase; Metastases; Metastasis; Patent applications; Phenotypes; Predation; Prostate cancer; Protein arrays; Royalties; United States > US

Adaptation of cancer cells to targeted therapy follows ecological paradigms observed in natural populations that encounter resource depletion and changing environments, including activation of pro-survival mechanisms, migration to new locations, and escape of predation. We identified the p38 MAPK pa...