Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation

• Published in: bioRxiv
• Main Authors: Borgman, Kyra J E, Flórez-Grau, Georgina, Ricci, Maria A, Manzo, Carlo, Lakadamyali, Melike, Cambi, Alessandra, Benítez-Ribas, Daniel, Campelo, Felix, Garcia-Parajo, Maria F
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.04.2020
• Subjects: Chromatin; Dendritic cells; Immunological tolerance; Macrophages; Nuclear transport; Protein-tyrosine kinase receptors; Signal transduction

MerTK is a transmembrane receptor tyrosine kinase (RTK) mainly expressed in dendritic cells (DCs) and macrophages where it plays an important role in immunotolerance, but also in activating oncogenic signalling pathways. Albeit MerTK is exploited as clinical target in cancer and auto-immune disorder...