Loss of heterochromatin and retrotransposon silencing constitute an early phase in oocyte aging

• Published in: bioRxiv
• Main Authors: Wasserzug-Pash, Peera, Rothman, Rachel, Reich, Eli, Schonberger, Oshrat, Weiss, Yifat, Srebnik, Naama, Cohen-Hadad, Yaara, Weintraub, Amir, Ben-Ami, Ido, Holzer, Hananel, Klutstein, Michael
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.10.2020
• Subjects: Age; Aging; Aneuploidy; Chromatin; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; Epigenetics; Heterochromatin; Localization; Oocytes; RNA processing; Transcription

Abstract Mammalian oocyte quality reduces with female age. A well-studied aspect of this deterioration is an age-associated rise in oocyte aneuploidy. We show that prior to the occurrence of significant aneuploidy (at the age of 9 months in mouse females), epigenetic changes occur and impact oocyte...