The novel M4 PAM PET tracer [11C] MK‐6884: a novel biomarker for measuring target engagement of muscarinic M4 positive allosteric modulators (PAMs) as well as cholinergic tone in patients with Alzheimer’s disease

Background The muscarinic acetylcholine receptor 4 (M4) has attracted attention as a target for treating neuropsychiatric symptoms, such as agitation and aggression, associated with Alzheimer’s disease. We have developed novel selective, potent, and in vivo suitable M4 positive allosteric modulators...

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Bibliographic Details
Published inAlzheimer's & dementia Vol. 18; no. S10
Main Authors Li, Wenping, Basile, Anthony S, Tong, Ling, Van Laere, Koen, Masdeu, Joseph C., Hostetler, Eric D, Marshall, Fiona, Uslaner, Jason M.
Format Journal Article
LanguageEnglish
Published 01.12.2022
Online AccessGet full text
ISSN1552-5260
1552-5279
DOI10.1002/alz.067249

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