3C pro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation
ABSTRACT Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the lea...
Saved in:
Published in | Journal of virology Vol. 88; no. 9; pp. 4908 - 4920 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.05.2014
|
Online Access | Get full text |
Cover
Loading…
Abstract | ABSTRACT
Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the leader proteinase (L
pro
) and 3C
pro
of FMDV are involved in the inhibition of type I IFN production. However, whether the proteins of FMDV can inhibit type I IFN signaling is less well understood. In this study, we first found that 3C
pro
of FMDV functioned to interfere with the JAK-STAT signaling pathway. Expression of 3C
pro
significantly reduced the transcript levels of IFN-stimulated genes (ISGs) and IFN-stimulated response element (ISRE) promoter activity. The protein level, tyrosine phosphorylation of STAT1 and STAT2, and their heterodimerization were not affected. However, the nuclear translocation of STAT1/STAT2 was blocked by the 3C
pro
protein. Further mechanistic studies demonstrated that 3C
pro
induced proteasome- and caspase-independent protein degradation of karyopherin α1 (KPNA1), the nuclear localization signal receptor for tyrosine-phosphorylated STAT1, but not karyopherin α2, α3, or α4. Finally, we showed that the protease activity of 3C
pro
contributed to the degradation of KPNA1 and thus blocked STAT1/STAT2 nuclear translocation. Taken together, results of our experiments describe for the first time a novel mechanism by which FMDV evolves to inhibit IFN signaling and counteract host innate antiviral responses.
IMPORTANCE
We show that 3C
pro
of FMDV antagonizes the JAK-STAT signaling pathway by blocking STAT1/STAT2 nuclear translocation. Furthermore, 3C
pro
induces KPNA1 degradation, which is independent of proteasome and caspase pathways. The protease activity of 3C
pro
contributes to the degradation of KPNA1 and governs the ability of 3C
pro
to inhibit the JAK-STAT signaling pathway. This study uncovers a novel mechanism evolved by FMDV to antagonize host innate immune responses. |
---|---|
AbstractList | ABSTRACT
Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the leader proteinase (L
pro
) and 3C
pro
of FMDV are involved in the inhibition of type I IFN production. However, whether the proteins of FMDV can inhibit type I IFN signaling is less well understood. In this study, we first found that 3C
pro
of FMDV functioned to interfere with the JAK-STAT signaling pathway. Expression of 3C
pro
significantly reduced the transcript levels of IFN-stimulated genes (ISGs) and IFN-stimulated response element (ISRE) promoter activity. The protein level, tyrosine phosphorylation of STAT1 and STAT2, and their heterodimerization were not affected. However, the nuclear translocation of STAT1/STAT2 was blocked by the 3C
pro
protein. Further mechanistic studies demonstrated that 3C
pro
induced proteasome- and caspase-independent protein degradation of karyopherin α1 (KPNA1), the nuclear localization signal receptor for tyrosine-phosphorylated STAT1, but not karyopherin α2, α3, or α4. Finally, we showed that the protease activity of 3C
pro
contributed to the degradation of KPNA1 and thus blocked STAT1/STAT2 nuclear translocation. Taken together, results of our experiments describe for the first time a novel mechanism by which FMDV evolves to inhibit IFN signaling and counteract host innate antiviral responses.
IMPORTANCE
We show that 3C
pro
of FMDV antagonizes the JAK-STAT signaling pathway by blocking STAT1/STAT2 nuclear translocation. Furthermore, 3C
pro
induces KPNA1 degradation, which is independent of proteasome and caspase pathways. The protease activity of 3C
pro
contributes to the degradation of KPNA1 and governs the ability of 3C
pro
to inhibit the JAK-STAT signaling pathway. This study uncovers a novel mechanism evolved by FMDV to antagonize host innate immune responses. |
Author | Zhao, Xiaomin Wang, Jinbao Liu, Jiyu Chen, Lei Cong, Xiaoyan Zhang, Yongguang Jiang, Ping Wan, Renzhong Yoo, Dongwan Wu, Xiangju Liu, Xing Sun, Wenbo Du, Yijun Wu, Jiaqiang Bi, Jingshan Guo, Lihui |
Author_xml | – sequence: 1 givenname: Yijun surname: Du fullname: Du, Yijun organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 2 givenname: Jingshan surname: Bi fullname: Bi, Jingshan organization: Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing, China – sequence: 3 givenname: Jiyu surname: Liu fullname: Liu, Jiyu organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 4 givenname: Xing surname: Liu fullname: Liu, Xing organization: Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing, China – sequence: 5 givenname: Xiangju surname: Wu fullname: Wu, Xiangju organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China, Key Laboratory of Animal Biotechnology and Disease Control and Prevention of Shandong Province, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, China – sequence: 6 givenname: Ping surname: Jiang fullname: Jiang, Ping organization: Key Laboratory of Animal Diseases Diagnostic and Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Ministry of Agriculture, Nanjing, China – sequence: 7 givenname: Dongwan surname: Yoo fullname: Yoo, Dongwan organization: Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA – sequence: 8 givenname: Yongguang surname: Zhang fullname: Zhang, Yongguang organization: State Key Laboratory of Veterinary Etiological Biology/National Foot and Mouth Disease Reference Laboratory/Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China – sequence: 9 givenname: Jiaqiang surname: Wu fullname: Wu, Jiaqiang organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 10 givenname: Renzhong surname: Wan fullname: Wan, Renzhong organization: Key Laboratory of Animal Biotechnology and Disease Control and Prevention of Shandong Province, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, China – sequence: 11 givenname: Xiaomin surname: Zhao fullname: Zhao, Xiaomin organization: Key Laboratory of Animal Biotechnology and Disease Control and Prevention of Shandong Province, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, China – sequence: 12 givenname: Lihui surname: Guo fullname: Guo, Lihui organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 13 givenname: Wenbo surname: Sun fullname: Sun, Wenbo organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 14 givenname: Xiaoyan surname: Cong fullname: Cong, Xiaoyan organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 15 givenname: Lei surname: Chen fullname: Chen, Lei organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China – sequence: 16 givenname: Jinbao surname: Wang fullname: Wang, Jinbao organization: Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China |
BookMark | eNotkM1OAjEUhRuDiYDufIA-gIXeaSnDElEUgz8JE-JucqfTwujYknaIwZ1v7qBuzpecnJzF1yMd550h5BL4ACBJhw_rxYALpVIG4oR0gU9SNhqB7JAu50nCRiJ9PSO9GN84BymV7JJvMaO74Km3dO59w9CV7NHvmy29qaLBaOi6CvtIp67BjXfVl4m02Rq6cI0J1gTv6KraOKwrt6Ev2Gw_8UCLA72uvX4_dqtsmsHwmAl92uvaYKBZQBfbATaVd-fk1GIdzcU_-ySb32aze7Z8vlvMpkumAVLBpBqjKgWXCMLKosQxlqVFjVbBqJCooBC6beXEtrSFkFKnClIOMEGjRZ9c_d3q4GMMxua7UH1gOOTA86O9vLWX_9rLQYgf3vZlpg |
CitedBy_id | crossref_primary_10_1038_cddis_2017_170 crossref_primary_10_3390_v12121348 crossref_primary_10_3389_fimmu_2021_571509 crossref_primary_10_3390_v8030082 crossref_primary_10_1007_s12250_019_00155_8 crossref_primary_10_1128_JVI_00238_21 crossref_primary_10_3389_fmicb_2021_762869 crossref_primary_10_3390_v13091776 crossref_primary_10_1016_j_virol_2017_06_023 crossref_primary_10_2174_1381612826666200109181238 crossref_primary_10_1155_2019_7398208 crossref_primary_10_1016_j_virol_2023_109944 crossref_primary_10_3390_v13071210 crossref_primary_10_1096_fj_201701351 crossref_primary_10_3389_fvets_2020_00465 crossref_primary_10_3389_fmicb_2021_737031 crossref_primary_10_1016_j_virol_2017_04_023 crossref_primary_10_1038_cddis_2016_489 crossref_primary_10_1155_2017_2481348 crossref_primary_10_3390_v14102129 crossref_primary_10_1038_s41420_021_00487_z crossref_primary_10_1016_j_gene_2016_03_027 crossref_primary_10_1111_tbed_12520 crossref_primary_10_1128_jvi_00612_22 crossref_primary_10_1016_j_virs_2023_03_003 crossref_primary_10_3390_pathogens9090729 crossref_primary_10_1002_rmv_2016 crossref_primary_10_1016_j_virol_2024_110070 crossref_primary_10_4049_jimmunol_2101042 crossref_primary_10_1096_fj_15_281410 crossref_primary_10_3390_v14020188 crossref_primary_10_4049_jimmunol_1701773 crossref_primary_10_3389_fimmu_2024_1395809 crossref_primary_10_3390_v13112118 crossref_primary_10_3390_pathogens10121566 crossref_primary_10_1096_fj_202101232RR crossref_primary_10_1021_jasms_0c00033 crossref_primary_10_1111_tra_12480 crossref_primary_10_1242_jcs_253237 crossref_primary_10_1016_j_vetmic_2018_11_016 crossref_primary_10_1016_j_vetvac_2023_100015 crossref_primary_10_1371_journal_ppat_1009057 crossref_primary_10_1007_s12250_020_00322_2 crossref_primary_10_1099_vir_0_068270_0 crossref_primary_10_1371_journal_ppat_1012104 crossref_primary_10_3389_fimmu_2017_01758 crossref_primary_10_3390_v15030666 crossref_primary_10_1074_jbc_M116_745729 crossref_primary_10_1128_JVI_00222_19 crossref_primary_10_1128_JVI_00361_21 crossref_primary_10_3390_v14092060 crossref_primary_10_3390_cells10020271 crossref_primary_10_1016_j_virol_2018_01_028 crossref_primary_10_3389_fcimb_2017_00252 crossref_primary_10_1128_jvi_00585_24 crossref_primary_10_1128_JVI_02086_19 crossref_primary_10_1016_j_vetmic_2022_109354 crossref_primary_10_1016_j_vetmic_2022_109596 crossref_primary_10_1038_s41419_018_0940_z crossref_primary_10_3390_ani12151995 crossref_primary_10_1002_eji_202048785 crossref_primary_10_1002_rmv_2206 crossref_primary_10_3389_fmicb_2018_02644 crossref_primary_10_1016_j_micpath_2017_09_039 crossref_primary_10_1128_jvi_00727_23 crossref_primary_10_1016_j_virusres_2015_01_012 crossref_primary_10_3389_fmicb_2018_02943 crossref_primary_10_1128_JVI_00124_19 crossref_primary_10_1016_j_virol_2015_08_005 crossref_primary_10_3390_v13030456 crossref_primary_10_3390_v13091765 crossref_primary_10_1042_BJ20141186 crossref_primary_10_1080_15384101_2016_1151584 crossref_primary_10_1186_s13567_015_0273_1 crossref_primary_10_1186_s12864_016_3176_2 crossref_primary_10_1016_j_cbpa_2018_09_021 crossref_primary_10_1016_j_virol_2019_07_009 crossref_primary_10_3389_fimmu_2020_580334 crossref_primary_10_1038_srep21888 crossref_primary_10_1128_JVI_00922_18 crossref_primary_10_3389_fmicb_2018_01862 crossref_primary_10_1016_j_vetmic_2022_109582 |
Cites_doi | 10.1016/S0959-440X(01)00264-0 10.1074/jbc.M400815200 10.1128/JVI.00447-11 10.1074/jbc.M413254200 10.1099/vir.0.83391-0 10.1371/journal.ppat.1001311 10.1371/journal.ppat.1002169 10.1007/3-540-27109-0_3 10.1128/JVI.01161-09 10.1016/j.virol.2011.12.011 10.1128/JVI.01782-06 10.1016/j.cell.2007.07.034 10.1038/ng1097 10.1128/CMR.17.2.465-493.2004 10.1128/JVI.01467-07 10.1038/nri1226 10.1016/j.virusres.2012.12.012 10.1128/JVI.02349-05 10.1128/JVI.00722-12 10.1128/JVI.06466-11 10.1006/viro.1995.0030 10.1007/3-540-27109-0_4 10.1128/JVI.06687-11 10.1016/j.virusres.2004.04.002 10.1128/JVI.76.9.4190-4198.2002 10.1128/JVI.03083-12 10.1128/JVI.01012-07 10.1371/journal.pone.0013927 10.1016/j.virusres.2009.11.016 10.1126/science.8197455 10.1073/pnas.0611506104 10.1038/ni1303 10.1038/nri2314 10.1128/JVI.01097-07 10.1371/journal.ppat.1003231 10.1016/j.virol.2006.09.049 10.1002/hep.25530 10.1089/0882824041310568 10.1002/hep.26064 10.1016/j.virol.2010.08.025 10.1006/viro.2002.1773 10.1128/JVI.78.11.5633-5641.2004 10.1128/JVI.80.4.1906-1914.2006 10.1093/emboj/21.7.1754 10.1073/pnas.0600007103 10.1128/JVI.00371-07 10.1073/pnas.96.23.13108 10.1016/0092-8674(91)90088-G 10.1128/JVI.02643-12 10.1128/JVI.02491-09 10.1128/JVI.01930-06 10.1128/JVI.00655-10 10.1128/JVI.01265-06 10.1126/science.1071545 10.1111/j.1600-065X.2007.00562.x 10.1016/j.bbrc.2010.07.044 |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.1128/JVI.03668-13 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1098-5514 |
Editor | Perlman, S. |
Editor_xml | – sequence: 1 givenname: S. surname: Perlman fullname: Perlman, S. |
EndPage | 4920 |
ExternalDocumentID | 10_1128_JVI_03668_13 |
GroupedDBID | --- -~X .55 .GJ 0R~ 18M 29L 2WC 39C 3O- 4.4 41~ 53G 5GY 5RE 5VS 6TJ 85S AAYJJ AAYXX ABPPZ ACGFO ACNCT ADBBV AENEX AFFNX AGVNZ AI. ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CITATION CS3 D0S DIK E3Z EBS EJD F20 F5P FRP GX1 H13 HYE HZ~ IH2 KQ8 MVM N9A O9- OHT OK1 P2P RHF RHI RNS RPM RSF TR2 UCJ UPT VH1 W2D W8F WH7 WOQ X7M Y6R YQT ZGI ZXP ~02 ~KM |
ID | FETCH-LOGICAL-c1183-467a6d304a13f4bda7addfacaf615b4a61b3cda749f3cdfb344c86180119aec3 |
ISSN | 0022-538X |
IngestDate | Thu Sep 12 17:36:18 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 9 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c1183-467a6d304a13f4bda7addfacaf615b4a61b3cda749f3cdfb344c86180119aec3 |
OpenAccessLink | https://jvi.asm.org/content/jvi/88/9/4908.full.pdf |
PageCount | 13 |
ParticipantIDs | crossref_primary_10_1128_JVI_03668_13 |
PublicationCentury | 2000 |
PublicationDate | 2014-05-00 |
PublicationDateYYYYMMDD | 2014-05-01 |
PublicationDate_xml | – month: 05 year: 2014 text: 2014-05-00 |
PublicationDecade | 2010 |
PublicationTitle | Journal of virology |
PublicationYear | 2014 |
References | e_1_3_2_26_2 e_1_3_2_49_2 e_1_3_2_28_2 e_1_3_2_41_2 e_1_3_2_20_2 e_1_3_2_43_2 e_1_3_2_22_2 e_1_3_2_45_2 e_1_3_2_24_2 e_1_3_2_47_2 e_1_3_2_9_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_54_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_52_2 e_1_3_2_5_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_3_2 e_1_3_2_14_2 e_1_3_2_35_2 e_1_3_2_56_2 e_1_3_2_50_2 e_1_3_2_27_2 e_1_3_2_48_2 e_1_3_2_29_2 e_1_3_2_40_2 e_1_3_2_21_2 e_1_3_2_42_2 e_1_3_2_23_2 e_1_3_2_44_2 e_1_3_2_25_2 e_1_3_2_46_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_17_2 e_1_3_2_6_2 e_1_3_2_19_2 e_1_3_2_30_2 e_1_3_2_53_2 e_1_3_2_32_2 e_1_3_2_51_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_57_2 e_1_3_2_4_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_55_2 e_1_3_2_2_2 |
References_xml | – ident: e_1_3_2_57_2 doi: 10.1016/S0959-440X(01)00264-0 – ident: e_1_3_2_11_2 doi: 10.1074/jbc.M400815200 – ident: e_1_3_2_16_2 doi: 10.1128/JVI.00447-11 – ident: e_1_3_2_34_2 doi: 10.1074/jbc.M413254200 – ident: e_1_3_2_40_2 doi: 10.1099/vir.0.83391-0 – ident: e_1_3_2_19_2 doi: 10.1371/journal.ppat.1001311 – ident: e_1_3_2_20_2 doi: 10.1371/journal.ppat.1002169 – ident: e_1_3_2_4_2 doi: 10.1007/3-540-27109-0_3 – ident: e_1_3_2_46_2 doi: 10.1128/JVI.01161-09 – ident: e_1_3_2_54_2 doi: 10.1016/j.virol.2011.12.011 – ident: e_1_3_2_49_2 doi: 10.1128/JVI.01782-06 – ident: e_1_3_2_14_2 doi: 10.1016/j.cell.2007.07.034 – ident: e_1_3_2_37_2 doi: 10.1038/ng1097 – ident: e_1_3_2_3_2 doi: 10.1128/CMR.17.2.465-493.2004 – ident: e_1_3_2_23_2 doi: 10.1128/JVI.01467-07 – ident: e_1_3_2_13_2 doi: 10.1038/nri1226 – ident: e_1_3_2_33_2 doi: 10.1016/j.virusres.2012.12.012 – ident: e_1_3_2_39_2 doi: 10.1128/JVI.02349-05 – ident: e_1_3_2_25_2 doi: 10.1128/JVI.00722-12 – ident: e_1_3_2_8_2 doi: 10.1128/JVI.06466-11 – ident: e_1_3_2_35_2 doi: 10.1006/viro.1995.0030 – ident: e_1_3_2_2_2 doi: 10.1007/3-540-27109-0_4 – ident: e_1_3_2_17_2 doi: 10.1128/JVI.06687-11 – ident: e_1_3_2_30_2 doi: 10.1016/j.virusres.2004.04.002 – ident: e_1_3_2_42_2 doi: 10.1128/JVI.76.9.4190-4198.2002 – ident: e_1_3_2_41_2 doi: 10.1128/JVI.03083-12 – ident: e_1_3_2_48_2 doi: 10.1128/JVI.01012-07 – ident: e_1_3_2_32_2 doi: 10.1371/journal.pone.0013927 – ident: e_1_3_2_27_2 doi: 10.1016/j.virusres.2009.11.016 – ident: e_1_3_2_12_2 doi: 10.1126/science.8197455 – ident: e_1_3_2_21_2 doi: 10.1073/pnas.0611506104 – ident: e_1_3_2_6_2 doi: 10.1038/ni1303 – ident: e_1_3_2_5_2 doi: 10.1038/nri2314 – ident: e_1_3_2_51_2 doi: 10.1128/JVI.01097-07 – ident: e_1_3_2_18_2 doi: 10.1371/journal.ppat.1003231 – ident: e_1_3_2_44_2 doi: 10.1016/j.virol.2006.09.049 – ident: e_1_3_2_45_2 doi: 10.1002/hep.25530 – ident: e_1_3_2_52_2 doi: 10.1089/0882824041310568 – ident: e_1_3_2_47_2 doi: 10.1002/hep.26064 – ident: e_1_3_2_28_2 doi: 10.1016/j.virol.2010.08.025 – ident: e_1_3_2_43_2 doi: 10.1006/viro.2002.1773 – ident: e_1_3_2_53_2 doi: 10.1128/JVI.78.11.5633-5641.2004 – ident: e_1_3_2_22_2 doi: 10.1128/JVI.80.4.1906-1914.2006 – ident: e_1_3_2_38_2 doi: 10.1093/emboj/21.7.1754 – ident: e_1_3_2_29_2 doi: 10.1073/pnas.0600007103 – ident: e_1_3_2_50_2 doi: 10.1128/JVI.00371-07 – ident: e_1_3_2_9_2 doi: 10.1073/pnas.96.23.13108 – ident: e_1_3_2_26_2 doi: 10.1016/0092-8674(91)90088-G – ident: e_1_3_2_55_2 doi: 10.1128/JVI.02643-12 – ident: e_1_3_2_15_2 doi: 10.1128/JVI.02491-09 – ident: e_1_3_2_56_2 doi: 10.1128/JVI.01930-06 – ident: e_1_3_2_36_2 doi: 10.1128/JVI.00655-10 – ident: e_1_3_2_31_2 doi: 10.1128/JVI.01265-06 – ident: e_1_3_2_10_2 doi: 10.1126/science.1071545 – ident: e_1_3_2_7_2 doi: 10.1111/j.1600-065X.2007.00562.x – ident: e_1_3_2_24_2 doi: 10.1016/j.bbrc.2010.07.044 |
SSID | ssj0014464 |
Score | 2.152159 |
Snippet | ABSTRACT
Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences.... |
SourceID | crossref |
SourceType | Aggregation Database |
StartPage | 4908 |
Title | 3C pro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation |
Volume | 88 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9tAEF1FVJV6qVpK1Q-o9tCe0AL2btb2EVIQjQQng3KzZm1vSCs5VRqrCrf-C34uM-uPLDQH2osdrWxH8bzMe7M7M8vYZw0AFkopaBNzoQKbC3NUgoh0oaMC9UMUUXHyxaU-v1LjyXAyGNx5WUv10hzktxvrSv7HqjiGdqUq2X-wbP9QHMDPaF88ooXx-CQbyxHlV5HeO5vPlwKqQlzQlnjUU5OWXfavZ4v6FzUIgCn-d2-pnUOXLGnLBbmK2ZSUeDWlXv03v2FFcvQECe6H69SdHqfk6egc7l9S62NYNP3QiQN7m_4tbql6zp-v_1o7Xz_7XvdgPHF5BGOaqb_xEoNmdTO8qh8NTTqSbecoArXOCPRqBtC1ThrWaVwtdTIlveb74jj2MJd4jpXWJz2SVokrodtAACEVNYyvvx0gNWsMkOWa6LrF_Uf812clungojDO8O3N3Z7Qd8rMwSoZRNw_Urk9hEK26PvT0u7qSijA-9L_bEzueaklfsZetRfhxg53XbFBW2-x5swHp6g37I0ccEcTnlj9EEG8RxB2CuIcgjgjiawTxHkG8RRA3K94hiDsEHTr88BY__AF-dlh6dpqOzkW7KYfIMRaVAokVdCGPFATSKlNAhAxpIQeL2tgo0IGROY6qxOLZGqlUHusgpt6CUObyLduq5lX5jnGUjqBBoVcY5konFp9TWBuEZRFgVK3Me_ale3nZz6b1SrbJRB-eeN1H9mKNzV22tVzU5R4qyqX55Ix7DwGgdxY |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=3C+pro+of+Foot-and-Mouth+Disease+Virus+Antagonizes+the+Interferon+Signaling+Pathway+by+Blocking+STAT1%2FSTAT2+Nuclear+Translocation&rft.jtitle=Journal+of+virology&rft.au=Du%2C+Yijun&rft.au=Bi%2C+Jingshan&rft.au=Liu%2C+Jiyu&rft.au=Liu%2C+Xing&rft.date=2014-05-01&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=88&rft.issue=9&rft.spage=4908&rft.epage=4920&rft_id=info:doi/10.1128%2FJVI.03668-13&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_JVI_03668_13 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon |