Differential Enantiomer-Specific Signaling of Cannabidiol at CB 1 Receptors

• Published in: Molecular pharmacology Vol. 102; no. 6; pp. 259 - 268
• Main Authors: Bosquez-Berger, Taryn, Wilson, Sierra, Iliopoulos-Tsoutsouvas, Christos, Jiang, Shan, Wager-Miller, Jim, Nikas, Spyros P, Mackie, Ken P, Makriyannis, Alexandros, Straiker, Alex
• Format: Journal Article
• Language: English
• Published: United States 01.12.2022
• Subjects: Cannabidiol - pharmacology; Cannabinoid Receptor Agonists - pharmacology; Dronabinol - pharmacology; Endocannabinoids; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction

The two main constituents of are Δ -tetrahydrocannabinol (THC) and cannabidiol (CBD). While Δ -THC pharmacology has been studied extensively, CBD-long considered inactive-is now the subject of vigorous research related to epilepsy, pain, and inflammation and is popularly embraced as a virtual cure-a...