A Non‐Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases

• Published in: Angewandte Chemie Vol. 130; no. 6; pp. 1592 - 1596
• Main Authors: Pöhler, Robert, Krahn, Jan H., van den Boom, Johannes, Dobrynin, Grzegorz, Kaschani, Farnusch, Eggenweiler, Hans‐Michael, Zenke, Frank T., Kaiser, Markus, Meyer, Hemmo
• Format: Journal Article
• Language: English; German
• Published: Weinheim Wiley Subscription Services, Inc 05.02.2018
• Subjects: AAA-ATPase; Adenosine triphosphatase; Allosteric properties; Allosterie; Chemistry; Circuits; Drug discovery; Inhibitors; p97; Ubiquitin; VPS4; Wirkstoffentwicklung

AAA ATPases have pivotal functions in diverse cellular processes essential for survival and proliferation. Revealing strategies for chemical inhibition of this class of enzymes is therefore of great interest for the development of novel chemotherapies or chemical tools. Here, we characterize the com...